MIR579

Summary

MIR579 (microRNA 579, HGNC:32835) is a microRNA gene on chromosome 5p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693164 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32835
Approved symbol	MIR579
Name	microRNA 579
Location	5p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-579
Ensembl gene	ENSG00000207956
Ensembl biotype	miRNA
Entrez	693164
RNAcentral	URS0000440A79 — miRNA, 98 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385221

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385221 — 1 exons

Exon	Start	End
ENSE00001500227	32394378	32394475

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 88.47.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	88.47	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.78	gold quality
bone marrow	UBERON:0002371	80.15	gold quality
kidney	UBERON:0002113	78.74	gold quality
duodenum	UBERON:0002114	78.25	gold quality
endometrium	UBERON:0001295	76.53	gold quality
monocyte	CL:0000576	76.37	gold quality
liver	UBERON:0002107	75.82	gold quality
muscle of leg	UBERON:0001383	75.41	gold quality
gastrocnemius	UBERON:0001388	75.27	gold quality
adrenal tissue	UBERON:0018303	75.04	gold quality
right lobe of liver	UBERON:0001114	74.11	gold quality
ectocervix	UBERON:0012249	73.53	gold quality
body of pancreas	UBERON:0001150	73.08	gold quality
blood	UBERON:0000178	73.05	gold quality
fundus of stomach	UBERON:0001160	72.91	gold quality
heart left ventricle	UBERON:0002084	72.25	gold quality
stomach	UBERON:0000945	72.04	gold quality
descending thoracic aorta	UBERON:0002345	71.94	gold quality
lymph node	UBERON:0000029	71.81	gold quality
adult mammalian kidney	UBERON:0000082	71.76	gold quality
popliteal artery	UBERON:0002250	71.60	gold quality
tibial artery	UBERON:0007610	71.57	gold quality
endocervix	UBERON:0000458	71.32	gold quality
urinary bladder	UBERON:0001255	71.27	gold quality
body of stomach	UBERON:0001161	71.18	gold quality
islet of Langerhans	UBERON:0000006	71.13	gold quality
placenta	UBERON:0001987	71.00	gold quality
heart	UBERON:0000948	70.97	gold quality
thoracic aorta	UBERON:0001515	70.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR (PMID:25799583)
• miR-579-3p controls melanoma progression and resistance to target therapy by targeting the 3’UTR of two oncoproteins: BRAF and MDM2. (PMID:27503895)
• these results indicated that STAT3-mediated downexpression of miR-579-3p caused resistance to vemurafenib. Our findings suggest novel approaches to overcome resistance to vemurafenib by combining vemurafenib with STAT3 sliencing or miR-579-3p overexpression. (PMID:30010109)
• Study shows a functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety. (PMID:30341278)
• The effect of miR-579 on the PI3K/AKT pathway in human glioblastoma PTEN mutant cell lines. (PMID:31243804)
• It has been shown that dysregulation of the circular RNA PWWP2A-miR-579 axis is involved in dexamethasone-induced cytotoxicity in human osteoblasts. (PMID:31376935)
• Role of miR-579-3p in the development of squamous cell lung carcinoma and the regulatory mechanisms. (PMID:31773684)
• Abiraterone induces SLCO1B3 expression in prostate cancer via microRNA-579-3p. (PMID:34031488)
• LncRNA HCG11/miR-579-3p/MDM2 axis modulates malignant biological properties in pancreatic carcinoma via Notch/Hes1 signaling pathway. (PMID:34230221)
• Circular RNA hsa_circ_0033144 (CircBCL11B) regulates oral squamous cell carcinoma progression via the miR-579/LASP1 axis. (PMID:34288804)
• Characterization of extracellular vesicle miRNA identified in peripheral blood of chronic pancreatitis patients. (PMID:34448998)
• miR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver. (PMID:35132819)
• Identification of a miRNA-based non-invasive predictive biomarker of response to target therapy in BRAF-mutant melanoma. (PMID:36438490)
• Circ_0007706 downregulation ameliorates neonatal hypoxic ischemic encephalopathy via regulating the miR-579-3p/TRAF6 axis. (PMID:36720318)

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.