MIR580

Summary

MIR580 (microRNA 580, HGNC:32836) is a microRNA gene on chromosome 5p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693165 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32836
Approved symbol	MIR580
Name	microRNA 580
Location	5p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-580
Ensembl gene	ENSG00000207756
Ensembl biotype	miRNA
Entrez	693165
RNAcentral	URS00006315BE — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385023

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385023 — 1 exons

Exon	Start	End
ENSE00001500030	36147892	36147988

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 85.21.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	85.21	gold quality
bone marrow	UBERON:0002371	81.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.25	gold quality
blood	UBERON:0000178	80.97	gold quality
monocyte	CL:0000576	78.96	gold quality
adrenal tissue	UBERON:0018303	78.86	gold quality
muscle of leg	UBERON:0001383	78.74	gold quality
gastrocnemius	UBERON:0001388	77.74	gold quality
fundus of stomach	UBERON:0001160	77.27	gold quality
islet of Langerhans	UBERON:0000006	76.95	gold quality
endometrium	UBERON:0001295	76.39	gold quality
vermiform appendix	UBERON:0001154	75.78	gold quality
placenta	UBERON:0001987	73.88	gold quality
right lobe of liver	UBERON:0001114	72.29	gold quality
heart left ventricle	UBERON:0002084	72.00	gold quality
liver	UBERON:0002107	71.92	gold quality
heart	UBERON:0000948	71.56	gold quality
body of pancreas	UBERON:0001150	70.75	gold quality
ascending aorta	UBERON:0001496	70.64	gold quality
lymph node	UBERON:0000029	70.45	gold quality
left coronary artery	UBERON:0001626	70.28	gold quality
thoracic aorta	UBERON:0001515	70.21	gold quality
body of stomach	UBERON:0001161	70.11	gold quality
stomach	UBERON:0000945	69.88	gold quality
tibial artery	UBERON:0007610	69.61	gold quality
right atrium auricular region	UBERON:0006631	69.04	gold quality
adrenal gland	UBERON:0002369	68.83	gold quality
Ammon’s horn	UBERON:0001954	68.72	gold quality
putamen	UBERON:0001874	68.70	gold quality
urinary bladder	UBERON:0001255	68.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• miR-580 is able to target the promoter region of TWIST1 and to control TWIST1 expression. (PMID:22266852)
• LINC00680 enhances hepatocellular carcinoma stemness behavior and chemoresistance by sponging miR-568 to upregulate AKT3. (PMID:33499874)
• CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARalpha/CCL2 pathway. (PMID:33891564)
• CircRAB3IP upregulates twist family BHLH transcription factor (TWIST1) to promote osteosarcoma progression by sponging miR-580-3p. (PMID:34224315)
• Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2’-5’-oligoadenylate synthetase 2 axis in acute myeloid leukemia. (PMID:34516354)
• SOX2-Induced Linc-ROR Upregulation Inhibits Gastric Carcinoma Cell Proliferation and Metastasis Via the miR-580-3p/ANXA10 Pathway. (PMID:36451051)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.