MIR581

Summary

MIR581 (microRNA 581, HGNC:32837) is a microRNA gene on chromosome 5q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693166 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32837
Approved symbol	MIR581
Name	microRNA 581
Location	5q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-581
Ensembl gene	ENSG00000207627
Ensembl biotype	miRNA
Entrez	693166
RNAcentral	URS000070DF56 — miRNA, 96 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384895

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384895 — 1 exons

Exon	Start	End
ENSE00001499902	53951504	53951599

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 92.16.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.16	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	90.40	gold quality
kidney	UBERON:0002113	85.24	gold quality
adrenal tissue	UBERON:0018303	82.74	gold quality
blood	UBERON:0000178	81.50	gold quality
calcaneal tendon	UBERON:0003701	79.14	gold quality
adult mammalian kidney	UBERON:0000082	78.06	gold quality
endometrium	UBERON:0001295	76.86	gold quality
liver	UBERON:0002107	76.76	gold quality
stomach	UBERON:0000945	76.65	gold quality
monocyte	CL:0000576	76.43	gold quality
lower esophagus mucosa	UBERON:0035834	74.42	gold quality
heart	UBERON:0000948	73.75	gold quality
left coronary artery	UBERON:0001626	73.32	gold quality
gastrocnemius	UBERON:0001388	73.16	gold quality
islet of Langerhans	UBERON:0000006	73.01	gold quality
intestine	UBERON:0000160	71.94	gold quality
corpus callosum	UBERON:0002336	71.56	gold quality
colon	UBERON:0001155	71.04	gold quality
adenohypophysis	UBERON:0002196	71.02	gold quality
right ovary	UBERON:0002118	70.96	gold quality
Ammon’s horn	UBERON:0001954	70.82	gold quality
smooth muscle tissue	UBERON:0001135	70.74	gold quality
heart left ventricle	UBERON:0002084	70.44	gold quality
lung	UBERON:0002048	69.67	gold quality
right atrium auricular region	UBERON:0006631	69.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.05	gold quality
body of pancreas	UBERON:0001150	69.04	gold quality
body of stomach	UBERON:0001161	68.75	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1 in HepG2 cells. (PMID:24913918)
• MiR-581/SMAD7 Axis Contributes to Colorectal Cancer Metastasis: A Bioinformatic and Experimental Validation-Based Study. (PMID:32899503)
• Long non-coding RNA COX7C-5 promotes hepatocellular carcinoma progression via miR-581/ZEB2 axis. (PMID:36273755)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.