MIR582

Summary

MIR582 (microRNA 582, HGNC:32838) is a microRNA gene on chromosome 5q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693167 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32838
Approved symbol	MIR582
Name	microRNA 582
Location	5q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-582
Ensembl gene	ENSG00000202601
Ensembl biotype	miRNA
Entrez	693167
RNAcentral	URS000068CA2F — miRNA, 98 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000365731

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000365731 — 1 exons

Exon	Start	End
ENSE00001440494	59703606	59703703

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 77.43.

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
caudate nucleus	UBERON:0001873	77.43	gold quality
body of pancreas	UBERON:0001150	76.76	gold quality
islet of Langerhans	UBERON:0000006	75.48	gold quality
blood	UBERON:0000178	75.23	gold quality
stomach	UBERON:0000945	74.83	gold quality
monocyte	CL:0000576	74.16	gold quality
gastrocnemius	UBERON:0001388	73.35	gold quality
adult mammalian kidney	UBERON:0000082	73.18	gold quality
body of stomach	UBERON:0001161	72.35	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.66	gold quality
ascending aorta	UBERON:0001496	71.42	gold quality
calcaneal tendon	UBERON:0003701	70.90	gold quality
liver	UBERON:0002107	70.46	gold quality
tibial artery	UBERON:0007610	70.19	gold quality
intestine	UBERON:0000160	69.83	gold quality
kidney	UBERON:0002113	69.50	gold quality
right atrium auricular region	UBERON:0006631	69.38	gold quality
heart left ventricle	UBERON:0002084	69.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.05	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.68	gold quality
descending thoracic aorta	UBERON:0002345	68.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.76	gold quality
colon	UBERON:0001155	67.41	gold quality
esophagus mucosa	UBERON:0002469	66.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.62	gold quality
thoracic mammary gland	UBERON:0005200	66.58	gold quality
fundus of stomach	UBERON:0001160	66.49	gold quality
omental fat pad	UBERON:0010414	66.04	gold quality
vagina	UBERON:0000996	65.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• The miR-582-5p could suppress both FOXO1 mRNA. (PMID:24205217)
• Concentration of serum MIR582 were altered in Deep vein thrombosis subjects. Statistical analysis showed a profile of serum MIR582 that might be useful as a biomarker for DVT detection after major orthopedic surgery. (PMID:25244974)
• The APP c.*331_*332del variant affected APP messenger RNA structure and binding of two microRNAs (miR-582-3p and miR-892b), providing a mechanism for the development of cerebral amyloid angiopathy. (PMID:25828868)
• miR-582-5p regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of CDK1 and AKT3, and indirectly inhibiting the expression of cyclinD1 (PMID:26002580)
• Data suggest that microRNA miR-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC) by targeting RAS-related GTP-binding protein (Rab27a), indicating a novel therapeutic strategy for patients with CRC. (PMID:26384136)
• miR-582-3p expression correlates with the overall- and recurrence-free-survival of non-small cell lung carcinoma patients, and miR-582-3p has an activating effect on Wnt/beta-catenin signalling (PMID:26468775)
• miR-582-5P plays an important role in the progression of colorectal cancer by inducing proliferation and may identify new targets for anti-cancer treatment. (PMID:27595705)
• miR-346 and miR-582-3p regulate EG-VEGF-induced trophoblast invasion through repressing MMP 2 and MMP 9, and may become novel diagnostic biomarkers or therapeutic targets for EG-VEGF-related obstetric disorders. (c) 2016 BioFactors, 43(2):210-219, 2017. (PMID:27619846)
• findings therefore indicate that miR582 promotes colorectal cancer progression by decreasing PTEN expression. (PMID:28713947)
• Results show that aberrant miR-346 and miR-582 expression profiles in maternal plasma, fetal cord plasma and placenta samples were shown to be associated with preeclampsia, preterm delivery, and small for gestational age. (PMID:28753968)
• Increased miR-582-5p expression could suppress cell proliferation, viability and promote cell apoptosis and G0/G1 arrest abilities via targeting AKT3. (PMID:29228422)
• miR-320d and miR-582 were found to be enriched in apoptotic vascular smooth muscle cells of aortic dissection patients. (PMID:29538087)
• miR-195 and miR-582 regulated NO release by targeting 3’-UTR of NOS3 post-transcriptionally in endothelial cells. (PMID:29948755)
• We showed that miR-582-5p inhibits non-small cell lung cancer (NSCLC) metastasis by targeting MAP3K2 expression and could be used as an independent prognostic biomarker for patients with NSCLC (PMID:30536321)
• that miR-582-5p is an important biomarker of knee osteoarthritis and is able to regulate osteogenic and adipogenic differentiation of MSCs via targeting Runx2 (PMID:31049977)
• Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/beta-catenin signaling, and suppress the growth and metastasis of colorectal cancer (PMID:31109967)
• miR-582-5p suppresses Non-small cell lung cancer cell lines’ growth and invasion via targeting oncoprotein NOTCH1. (PMID:31170211)
• The miR-582/CD1B Axis Is Involved in Regulation of Dendritic Cells and Is Associated with Clinical Outcomes in Advanced Lung Adenocarcinoma. (PMID:32258122)
• miR-582-5p serves as an antioncogenic biomarker in intermediate risk AML with normal cytogenetics and could inhibit proliferation and induce apoptosis of leukemia cells. (PMID:32543749)
• Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis. (PMID:32768929)
• LINC00641/miR-582-5p mediate oxaliplatin resistance by activating autophagy in gastric adenocarcinoma. (PMID:32917936)
• Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis. (PMID:32977948)
• MiR-582-3p alleviates osteoarthritis progression by targeting YAP1. (PMID:33190006)
• MiR-582-5p inhibits the growth and invasion of osteosarcoma cell by targeting NOVA1. (PMID:33215417)
• LncRNA UCA1 stimulates the repair of hyperglycemic vascular smooth muscle cells through targeting miR-582-5p. (PMID:33378036)
• The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway. (PMID:33707625)
• miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2. (PMID:34357507)
• TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer. (PMID:34516342)
• MiR-582-3p participates in the regulation of biological behaviors of A549 cells by ambient PM2.5 exposure. (PMID:34590234)
• Down-regulated expression of miR-582 predicts poor prognosis and facilitates melanoma progression by targeting FOXC1. (PMID:34628519)
• CircularRNA_0119872 regulates the microRNA-582-3p/E2F transcription factor 3 pathway to promote the progression of malignant melanoma. (PMID:34644734)
• The miRNA mir-582-3p suppresses ovarian cancer progression by targeting AKT/MTOR signaling via lncRNA TUG1. (PMID:34793263)
• Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway. (PMID:34825699)
• Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis. (PMID:34861798)
• Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis. (PMID:34898351)
• MicroRNA-582-5p promotes triple-negative breast cancer invasion and metastasis by antagonizing CMTM8. (PMID:34978519)
• MicroRNA-582-5p regulates cell invasion in bladder cancer through targeting Forkhead Box G1. (PMID:34979422)
• LncRNA HOXA10-AS Activated by E2F1 Facilitates Proliferation and Migration of Nasopharyngeal Carcinoma Cells Through Sponging miR-582-3p to Upregulate RAB31. (PMID:35072529)
• ILF3 represses repeat-derived microRNAs targeting RIG-I mediated type I interferon response. (PMID:35120969)
• miR-582 Suppresses the Proliferation of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells and Protects Them From Natural Killer Cell-Mediated Cytotoxicity. (PMID:35514986)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir582	ENSMUSG00000076946
rattus_norvegicus	Mir582	ENSRNOG00000040434

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.