MIR583

Summary

MIR583 (microRNA 583, HGNC:32839) is a microRNA gene on chromosome 5q15.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693168 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32839
Approved symbol	MIR583
Name	microRNA 583
Location	5q15
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-583
Ensembl gene	ENSG00000207578
Ensembl biotype	miRNA
Entrez	693168
RNAcentral	URS00006FBE08 — miRNA, 75 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384846

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384846 — 1 exons

Exon	Start	End
ENSE00001499853	96079138	96079212

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 78.49.

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	78.49	gold quality
blood	UBERON:0000178	77.43	gold quality
body of stomach	UBERON:0001161	77.20	gold quality
liver	UBERON:0002107	77.11	gold quality
adrenal tissue	UBERON:0018303	75.86	gold quality
lower esophagus mucosa	UBERON:0035834	74.98	gold quality
kidney	UBERON:0002113	73.79	gold quality
stomach	UBERON:0000945	72.84	gold quality
thoracic mammary gland	UBERON:0005200	70.60	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.77	gold quality
adult mammalian kidney	UBERON:0000082	69.64	gold quality
urinary bladder	UBERON:0001255	68.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.69	gold quality
heart left ventricle	UBERON:0002084	67.60	gold quality
body of pancreas	UBERON:0001150	67.44	gold quality
granulocyte	CL:0000094	66.67	gold quality
right atrium auricular region	UBERON:0006631	66.15	gold quality
tibial artery	UBERON:0007610	65.72	gold quality
ascending aorta	UBERON:0001496	65.64	gold quality
esophagus mucosa	UBERON:0002469	65.23	gold quality
intestine	UBERON:0000160	64.53	gold quality
amygdala	UBERON:0001876	64.52	gold quality
omental fat pad	UBERON:0010414	64.39	gold quality
prostate gland	UBERON:0002367	64.17	gold quality
left adrenal gland cortex	UBERON:0035825	64.02	gold quality
vagina	UBERON:0000996	63.97	gold quality
right ovary	UBERON:0002118	63.84	gold quality
anterior cingulate cortex	UBERON:0009835	63.74	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.48	gold quality
substantia nigra	UBERON:0002038	63.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC. (PMID:32366862)
• miR583 inhibits the proliferation and invasion of prostate cancer cells by targeting JAK1. (PMID:33495837)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.