MIR585

Summary

MIR585 (microRNA 585, HGNC:32841) is a microRNA gene on chromosome 5q35.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693170 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32841
Approved symbol	MIR585
Name	microRNA 585
Location	5q35.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-585
Ensembl gene	ENSG00000207619
Ensembl biotype	miRNA
Entrez	693170
RNAcentral	URS000075EBA2 — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384887

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384887 — 1 exons

Exon	Start	End
ENSE00001499894	169263601	169263694

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 76.46.

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	76.46	gold quality
lung	UBERON:0002048	75.46	gold quality
monocyte	CL:0000576	74.08	gold quality
kidney	UBERON:0002113	73.01	gold quality
stomach	UBERON:0000945	72.89	gold quality
ascending aorta	UBERON:0001496	70.84	gold quality
blood	UBERON:0000178	70.19	gold quality
tibial artery	UBERON:0007610	69.08	gold quality
heart	UBERON:0000948	68.00	gold quality
right atrium auricular region	UBERON:0006631	67.75	gold quality
vagina	UBERON:0000996	67.43	gold quality
Ammon’s horn	UBERON:0001954	66.81	gold quality
omental fat pad	UBERON:0010414	66.74	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.43	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.38	gold quality
left ovary	UBERON:0002119	66.06	gold quality
left coronary artery	UBERON:0001626	65.40	gold quality
right frontal lobe	UBERON:0002810	65.36	gold quality
transverse colon	UBERON:0001157	64.79	gold quality
endocervix	UBERON:0000458	64.18	gold quality
cerebellar hemisphere	UBERON:0002245	64.01	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.43	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.93	gold quality
myometrium	UBERON:0001296	62.49	gold quality
skin of abdomen	UBERON:0001416	62.09	gold quality
skin of leg	UBERON:0001511	62.03	gold quality
caudate nucleus	UBERON:0001873	61.74	gold quality
spleen	UBERON:0002106	61.73	gold quality
anterior cingulate cortex	UBERON:0009835	60.75	gold quality
amygdala	UBERON:0001876	59.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• miR-585 probably has an inhibitory effect on tumor growth and is a prognostic biomarker of non-small-cell lung cancer (PMID:27743168)
• MicroRNA-585 suppresses tumor proliferation and migration in gastric cancer by directly targeting MAPK1. (PMID:29550487)
• LINC01436 Inhibited miR-585-3p Expression and Upregulated MAPK1 Expression to Promote Gastric Cancer Progression. (PMID:32820394)
• Identification and validation of a miRNA-based prognostic signature for cervical cancer through an integrated bioinformatics approach. (PMID:33335254)
• Research on correlations of miR-585 expression with progression and prognosis of triple-negative breast cancer. (PMID:33826023)
• MiR-585-3p suppresses tumor proliferation and migration by directly targeting CAPN9 in high grade serous ovarian cancer. (PMID:34238324)
• Study on the Function and Mechanism of miR-585-3p Inhibiting the Progression of Ovarian Cancer Cells by Targeting FSCN1 to Block the MAPK Signaling Pathway. (PMID:35602576)
• MiR-585-5p impedes gastric cancer proliferation and metastasis by orchestrating the interactions among CREB1, MAPK1 and MITF. (PMID:36268034)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.