MIR586

Summary

MIR586 (microRNA 586, HGNC:32842) is a microRNA gene on chromosome 6p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693171 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32842
Approved symbol	MIR586
Name	microRNA 586
Location	6p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-586
Ensembl gene	ENSG00000207769
Ensembl biotype	miRNA
Entrez	693171
RNAcentral	URS0000652679 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385035

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385035 — 1 exons

Exon	Start	End
ENSE00001500042	45197674	45197770

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 84.20.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	84.20	gold quality
monocyte	CL:0000576	81.51	gold quality
stomach	UBERON:0000945	78.42	gold quality
gastrocnemius	UBERON:0001388	76.73	gold quality
adrenal tissue	UBERON:0018303	76.58	gold quality
heart	UBERON:0000948	74.44	gold quality
lung	UBERON:0002048	73.84	gold quality
blood	UBERON:0000178	73.23	gold quality
calcaneal tendon	UBERON:0003701	70.65	gold quality
intestine	UBERON:0000160	69.86	gold quality
endometrium	UBERON:0001295	68.52	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.07	gold quality
left lobe of thyroid gland	UBERON:0001120	68.01	gold quality
minor salivary gland	UBERON:0001830	66.87	gold quality
omental fat pad	UBERON:0010414	65.44	gold quality
left adrenal gland	UBERON:0001234	65.15	gold quality
skin of abdomen	UBERON:0001416	64.50	gold quality
vagina	UBERON:0000996	64.30	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.07	gold quality
thoracic mammary gland	UBERON:0005200	62.46	gold quality
corpus callosum	UBERON:0002336	61.27	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.86	gold quality
prostate gland	UBERON:0002367	59.25	gold quality
colon	UBERON:0001155	59.07	gold quality
spleen	UBERON:0002106	59.04	gold quality
right hemisphere of cerebellum	UBERON:0014890	58.79	gold quality
skin of leg	UBERON:0001511	58.00	gold quality
tibial nerve	UBERON:0001323	56.55	gold quality
left testis	UBERON:0004533	49.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Authors found evidence of Mendelian Transmission Distortion in the region harboring MIRN586 in one of the HapMap populations. (PMID:19259136)
• Results suggest that DSPP is regulated post-transcriptionally by mir32, mir885-5p and mir586 during odontoblast differentiation. (PMID:21687927)
• The plasma level of miR-586 at day 7 after allo-HSCT would be a potential biomarker for predicting the occurrence of aGVHD. (PMID:26051902)
• Study reveals SGK1 inhibition with miR-576-3p or pharmacologically inhibits migration and invasion of lung adenocarcinoma. (PMID:30257988)
• Exosomal circ_0001190 Regulates the Progression of Gastric Cancer via miR-586/SOSTDC1 Axis. (PMID:35138469)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.