MIR587

Summary

MIR587 (microRNA 587, HGNC:32843) is a microRNA gene on chromosome 6q21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693172 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32843
Approved symbol	MIR587
Name	microRNA 587
Location	6q21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-587
Ensembl gene	ENSG00000207577
Ensembl biotype	miRNA
Entrez	693172
RNAcentral	URS000075E1D5 — miRNA, 96 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384845

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384845 — 1 exons

Exon	Start	End
ENSE00001499852	106784125	106784220

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 83.15.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	83.15	gold quality
adrenal tissue	UBERON:0018303	81.78	gold quality
right lobe of liver	UBERON:0001114	80.58	gold quality
body of pancreas	UBERON:0001150	79.18	gold quality
monocyte	CL:0000576	77.83	gold quality
islet of Langerhans	UBERON:0000006	76.37	gold quality
kidney	UBERON:0002113	75.91	gold quality
metanephros cortex	UBERON:0010533	75.72	gold quality
multicellular organism	UBERON:0000468	74.67	gold quality
adult mammalian kidney	UBERON:0000082	73.62	gold quality
gall bladder	UBERON:0002110	73.24	gold quality
body of stomach	UBERON:0001161	72.51	gold quality
stomach	UBERON:0000945	72.32	gold quality
left ovary	UBERON:0002119	72.00	gold quality
endometrium	UBERON:0001295	71.53	gold quality
blood	UBERON:0000178	71.50	gold quality
lung	UBERON:0002048	71.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.49	gold quality
heart	UBERON:0000948	70.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.16	gold quality
tibial artery	UBERON:0007610	69.08	gold quality
left lobe of thyroid gland	UBERON:0001120	68.04	gold quality
body of uterus	UBERON:0009853	66.60	gold quality
intestine	UBERON:0000160	65.54	gold quality
vagina	UBERON:0000996	65.14	gold quality
myometrium	UBERON:0001296	65.14	gold quality
transverse colon	UBERON:0001157	64.69	gold quality
minor salivary gland	UBERON:0001830	64.68	gold quality
esophagus mucosa	UBERON:0002469	64.22	gold quality
skin of leg	UBERON:0001511	64.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. (PMID:26247730)
• The decreased expression of miR-587 in serum is a potential diagnostic marker and in-dependent risk factor in patients with metabolic syndrome (MS). (PMID:31307169)
• Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs. (PMID:31747371)
• The lncRNA RP11-142A22.4 promotes adipogenesis by sponging miR-587 to modulate Wnt5beta expression. (PMID:32561739)
• miR-587 promotes cervical cancer by repressing interferon regulatory factor 6. (PMID:32749750)
• MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA. (PMID:32964027)
• MiR-587 acts as an oncogene in non-small-cell lung carcinoma via reducing CYLD expression. (PMID:33378022)
• CircRNA CircZMYM4 inhibits the growth and metastasis of lung adenocarcinoma via the miR-587/ODAM pathway. (PMID:34634673)
• CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587. (PMID:35183197)
• Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer. (PMID:35311457)
• LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis. (PMID:36017912)
• Overexpression of lncRNA A2M-AS1 inhibits cell growth and aggressiveness via regulating the miR-587/bone morphogenetic protein 3 axis in lung adenocarcinoma. (PMID:36461613)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.