MIR588

Summary

MIR588 (microRNA 588, HGNC:32844) is a microRNA gene on chromosome 6q22.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693173 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32844
Approved symbol	MIR588
Name	microRNA 588
Location	6q22.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-588
Ensembl gene	ENSG00000207632
Ensembl biotype	miRNA
Entrez	693173
RNAcentral	URS000075C40E — miRNA, 83 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384900

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384900 — 1 exons

Exon	Start	End
ENSE00001499907	126484631	126484713

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 88.66.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	88.66	gold quality
heart	UBERON:0000948	81.52	gold quality
stomach	UBERON:0000945	79.23	gold quality
monocyte	CL:0000576	77.99	gold quality
endometrium	UBERON:0001295	74.46	gold quality
smooth muscle tissue	UBERON:0001135	74.12	gold quality
gastrocnemius	UBERON:0001388	73.27	gold quality
body of stomach	UBERON:0001161	72.64	gold quality
ascending aorta	UBERON:0001496	68.79	gold quality
tibial artery	UBERON:0007610	68.71	gold quality
lung	UBERON:0002048	68.32	gold quality
body of pancreas	UBERON:0001150	67.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.43	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.08	gold quality
endocervix	UBERON:0000458	66.89	gold quality
rectum	UBERON:0001052	66.78	gold quality
left adrenal gland	UBERON:0001234	66.77	gold quality
heart left ventricle	UBERON:0002084	66.61	gold quality
myometrium	UBERON:0001296	66.60	gold quality
right frontal lobe	UBERON:0002810	66.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.39	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.08	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.96	gold quality
skin of leg	UBERON:0001511	65.72	gold quality
adipose tissue	UBERON:0001013	65.53	gold quality
substantia nigra	UBERON:0002038	65.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.69	gold quality
omental fat pad	UBERON:0010414	64.60	gold quality
esophagus mucosa	UBERON:0002469	64.44	gold quality
vagina	UBERON:0000996	64.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• The overexpression of miR588 in lung squamous cell carcinoma cells reduced the mRNA and protein levels of progranulin (GRN), whereas miR588 silencing increased the expression of GRN. (PMID:27571908)
• MicroRNA-588 regulates migration capacity and invasiveness of renal cancer cells by targeting EIF5A2. (PMID:31841179)
• miR-588 is a prognostic marker in gastric cancer. (PMID:33323542)
• Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) progression by modulating the miR-588/CXCR4 axis. (PMID:34015764)
• SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis. (PMID:35080988)
• MicroRNA-588 regulates the invasive, migratory and vasculogenic mimicry-forming abilities of hypoxic glioma cells by targeting ROBO1. (PMID:36459288)
• CircECE1 promotes osteosarcoma progression through regulating RAB3D by sponging miR-588. (PMID:37559140)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.