MIR589

Summary

MIR589 (microRNA 589, HGNC:32845) is a microRNA gene on chromosome 7p22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693174 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32845
Approved symbol	MIR589
Name	microRNA 589
Location	7p22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-589
Ensembl gene	ENSG00000207973
Ensembl biotype	miRNA
Entrez	693174
RNAcentral	URS000064C5B0 — miRNA, 99 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385238

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385238 — 1 exons

Exon	Start	End
ENSE00001500244	5495819	5495917

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 89.18.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	89.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.89	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.43	gold quality
bone marrow	UBERON:0002371	85.56	gold quality
monocyte	CL:0000576	82.18	gold quality
skeletal muscle tissue	UBERON:0001134	82.11	gold quality
muscle of leg	UBERON:0001383	78.34	gold quality
gastrocnemius	UBERON:0001388	77.70	gold quality
blood	UBERON:0000178	76.74	gold quality
body of stomach	UBERON:0001161	76.37	gold quality
heart left ventricle	UBERON:0002084	76.20	gold quality
stomach	UBERON:0000945	76.10	gold quality
islet of Langerhans	UBERON:0000006	75.58	gold quality
body of pancreas	UBERON:0001150	75.12	gold quality
adult mammalian kidney	UBERON:0000082	74.79	gold quality
heart	UBERON:0000948	74.75	gold quality
urinary bladder	UBERON:0001255	74.48	gold quality
lung	UBERON:0002048	74.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.40	gold quality
liver	UBERON:0002107	74.34	gold quality
upper lobe of left lung	UBERON:0008952	73.95	gold quality
endometrium	UBERON:0001295	73.79	gold quality
left adrenal gland cortex	UBERON:0035825	73.56	gold quality
left coronary artery	UBERON:0001626	73.44	gold quality
lower esophagus	UBERON:0013473	73.38	gold quality
smooth muscle tissue	UBERON:0001135	73.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	73.36	gold quality
right atrium auricular region	UBERON:0006631	73.26	gold quality
skin of leg	UBERON:0001511	73.16	gold quality
colon	UBERON:0001155	73.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• miRNA589 mediates TGFbeta1 induced epithelial-mesenchymal transition in human peritoneal mesothelial cells. (PMID:23118514)
• microRNA222 and microRNA589 were pivotal for the development of intervertebral disc degeneration (PMID:26134418)
• Results show that miR-589 is down-regulated in CD90+ cancer stem cells in hepatocellular carcinoma (HCC) cells. MiR-589 down-regulates the stemness characteristics of CD90+ cancer stem cells in part by silencing MAP3K8. (PMID:27835990)
• miR-21 and miR-589 showed consistently significant relation with peritoneal transport (PMID:27867039)
• These findings demonstrate a novel mechanism for deregulation of HDAC5 in non-small cell lung cancer (NSCLC)and suggest that miR5895p/HDAC5 pathway may represent a new prognostic biomarker and therapeutic target against NSCLC. (PMID:28440397)
• Data report that miR-589-5p is elevated in hepatocellular carcinoma (HCC) tissues, which is caused by recurrent gains. Its overexpression correlates with poor overall and relapse-free survival in HCC patients. These findings demonstrate miR-589-5 promotes the cancer stem cell characteristics and chemoresistance via multiple negative regulators of STAT3 signaling pathway leading to its constitutive activation. (PMID:29196128)
• The edited version of miR-589-3p inhibits glioblastoma cell proliferation, migration and invasion, while the unedited version boosts cell proliferation and motility/invasion. (PMID:29267965)
• miR-589-5p facilitated the growth of liver cancer cells by targeting MIG-6 and could be a prognosis biomarker for hepatocellular carcinoma (PMID:30249105)
• results show that dysregulation of circPRKCI-miR-545/589-E2F7 axis mediated H2O2-induced neuronal cell injury; targeting this novel cascade could be a fine strategy to protect neurons from oxidative stress (PMID:31053300)
• miR5895p may act as a tumor suppressor in prostate cancer by targeting CCL5 (PMID:31173214)
• Low miR589 expression is associated with Cell Proliferation, Cell Migration and Invasion in Endometrial Carcinoma. (PMID:31424277)
• Cyclic RNA hsa_circ_0091017 inhibits proliferation, migration and invasiveness of bladder cancer cells by binding to microRNA-589-5p. (PMID:31957821)
• miR5893p sponged by the lncRNA TINCR inhibits the proliferation, migration and invasion and promotes the apoptosis of breast cancer cells by suppressing the Akt pathway via IGF1R. (PMID:32705168)
• Long non-coding RNA CCDC183-AS1 acts AS a miR-589-5p sponge to promote the progression of hepatocellular carcinoma through regulating SKP1 expression. (PMID:33541391)
• Circ_0003423 Alleviates ox-LDL-Induced Human Brain Microvascular Endothelial Cell Injury via the miR-589-5p/TET2 Network. (PMID:34226983)
• Downregulation of circ-UBAP2 ameliorates oxidative stress and dysfunctions of human retinal microvascular endothelial cells (hRMECs) via miR-589-5p/EGR1 axis. (PMID:34608841)
• Identification and Characterization of the Roles of circCASP9 in Gastric Cancer Based on a circRNA-miRNA-mRNA Regulatory Network. (PMID:35320976)
• miR-589-5p Inhibits Cell Proliferation by Targeting Histone Deacetylase 3 in Triple Negative Breast Cancer. (PMID:35840467)
• Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis. (PMID:36643863)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.