MIR590

Summary

MIR590 (microRNA 590, HGNC:32846) is a microRNA gene on chromosome 7q11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693175 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32846
Approved symbol	MIR590
Name	microRNA 590
Location	7q11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-590
Ensembl gene	ENSG00000207741
Ensembl biotype	miRNA
OMIM	615070
Entrez	693175
RNAcentral	URS00004AE041 — miRNA, 97 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385008

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385008 — 1 exons

Exon	Start	End
ENSE00001500015	74191198	74191294

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 97.96.

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	97.96	gold quality
vermiform appendix	UBERON:0001154	93.52	gold quality
adrenal tissue	UBERON:0018303	93.00	gold quality
monocyte	CL:0000576	92.90	gold quality
mucosa of stomach	UBERON:0001199	92.46	gold quality
rectum	UBERON:0001052	92.20	gold quality
endometrium	UBERON:0001295	91.87	gold quality
body of pancreas	UBERON:0001150	91.78	gold quality
right uterine tube	UBERON:0001302	90.76	gold quality
placenta	UBERON:0001987	90.39	gold quality
smooth muscle tissue	UBERON:0001135	90.32	gold quality
right ovary	UBERON:0002118	90.00	gold quality
body of stomach	UBERON:0001161	89.72	gold quality
left uterine tube	UBERON:0001303	89.63	gold quality
stomach	UBERON:0000945	89.47	gold quality
granulocyte	CL:0000094	89.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.13	gold quality
zone of skin	UBERON:0000014	88.84	gold quality
skin of abdomen	UBERON:0001416	88.82	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.80	gold quality
skin of leg	UBERON:0001511	88.79	gold quality
small intestine	UBERON:0002108	88.66	gold quality
pancreas	UBERON:0001264	88.25	gold quality
fallopian tube	UBERON:0003889	88.00	gold quality
body of uterus	UBERON:0009853	87.98	gold quality
ovary	UBERON:0000992	87.84	gold quality
transverse colon	UBERON:0001157	87.62	gold quality
fundus of stomach	UBERON:0001160	87.62	gold quality
left ovary	UBERON:0002119	87.37	gold quality
tonsil	UBERON:0002372	87.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• hnRNP-A1 and its transcription regulatory factor miR-590-3p are disregulated in patients with Alzheimer disease, and the hnRNP-A1 rs7967622 C/C genotype is likely a risk factor for frontotemporal lobar degeneration in male populations. (PMID:21548758)
• miR-590-5p promotes proliferation and invasion in human hepatocellular carcinoma cells by directly targeting TGF-beta RII. (PMID:22684895)
• down-regulation of miR-590-5P is involved in hepatocellular carcinoma and the restoration of miR-590-5P can impair the growth of cancer cells (PMID:23598417)
• this study identified the role of miR-590-5p, serving as an oncomir in clear cell renal carcinoma (ccRCC), and our findings provide a potential target for the treatment of ccRCC. (PMID:24063284)
• The findings of this study contribute to current understanding of the functions of miR-590-5p in cervical cancer (PMID:24288179)
• Data indicate that microRNA-590 (miR-590) can directly target the 3’UTR of lipoprotein lipase (LPL). (PMID:25149060)
• these results suggest that there is a negative feedback expression of pre-mir-590 and its putative target gene, ATF-3 in human breast cancer cells. (PMID:25150595)
• data suggest an inhibitory role of miR-590 during the cardiac differentiation of CDCs which its suppression might elevate the rate of differentiation. (PMID:25163461)
• miR-590 is a novel epithelial-to-mesenchymal transition -suppressive microRNA, which targets Transforming growth factorbeta receptor 2. (PMID:26459119)
• Findings suggest that the upregulation of miR-590-5p promotes cellular malignant behavior via the target gene TGFbetaRII in vulvar squamous cell carcinoma. (PMID:26498065)
• Our study first indicates that miR-590-3p functions as a suppressor of GBM EMT and metastasis by targeting ZEB1 and ZEB2, and it may be a therapeutic target for metastatic GBM. (PMID:26556542)
• The overexpression of miR590 inhibited oxLDLinduced endothelial cell apoptosis, expression of p53 and Bax, reduction of Bcl2 and activation of caspase3. (PMID:26648441)
• The role of miR-590-5p in endothelial cell apoptosis is investigated.MiR-590-5p downregulation promoted Ang II-induced endothelial cell apoptosis by elevating LOX-1 expression and consequently increasing reactive oxygen species generation. (PMID:26906623)
• show that MiR-590-5p inhibits angiogenesis by targeting LOX-1 and suppressing redox-sensitive signals (PMID:26932825)
• miR-590 inhibits RB1 and promotes proliferation and invasion of T-cell acute lymphoblastic leukaemia cells (PMID:27036041)
• JMJD1C is one of the target genes of hsa-miR-590- 3p. (PMID:27064872)
• miR-590-5p promotes osteoblast differentiation by indirectly protecting and stabilizing the Runx2 protein by targeting Smad7 gene expression. (PMID:27192628)
• rs6971711, C57T SNP is common in individuals of African ancestry. SNP frequency was higher in African American hypertrophic cardiomyopathy patients than ethnically-matched controls , but the difference was not statistically significant. Presence of this SNP resulted in markedly lower levels of mature miR-590-5p and miR-590-3p in vitro. (PMID:27196440)
• These result suggested that miR-590-3p can promote osteogenic differentiation via suppressing APC expression and stabilizing beta-catenin. (PMID:27586273)
• these data establish miR-590-5p as an anti-onco-miR that inhibits colorectal cancer angiogenesis and metastasis through a new mechanism involving NF90/VEGFA signaling axis. (PMID:27735951)
• data reveal miR-590 as a tumor suppressor in NSCLC, which is at least partially mediated through targeting of ADAM9. Restoration of miR-590 may provide a promising therapeutic strategy for NSCLC. (PMID:27770372)
• the present study identified the interaction of miR-590-3p and TFAM in colon cancer. TFAM was identified as a target of miR-590-3p, and miR-590-3p enhanced the proliferation of SW480 cells. (PMID:27878255)
• MiR-590-5p is downregulated in A375 cells, and inhibits the invasion and migration of A375 cells by directly regulating the expression of YAP1. (PMID:28274310)
• microRNA-590-3p is a potential onco-microRNA that participates in carcinogenesis of human prostate cancer by suppressing inositol polyphosphate 4-phosphatase type II expression and involving the Akt/FoxO3a pathway. (PMID:28345464)
• Upregulation of transcriptional enhancer activator domain 1 was found in hepatocellular carcinoma tissues and inversely correlated with miR-590-3p. Our results indicate a tumor suppressor role of miR-590-3p in hepatocellular carcinoma through targeting transcriptional enhancer activator domain 1 and suggest its use in the diagnosis and prognosis of liver cancer. (PMID:28349829)
• Data reported miR-590-3p was down-regulated in intrahepatic cholangiocarcinoma (ICC) tissues, sera, and cell lines. Serum miR-590-3p was diagnostic and prognostic biomarker for ICC patients. Moreover, overexpression of miR-590-3p could suppress cell migration, cell invasion, and EMT process by directly targeting SIP1. (PMID:28423728)
• DICER1-miR-590-5p-YAP1 axis was dysregulated in colorectal carcinoma specimens and affected patient survival. Cell-cell contact inhibition is crucial to prevent uncontrolled cell proliferation. (PMID:28433598)
• Although miR-590 showed good results in this study, further studies are required to investigate the role of miR-590 in breast cancer therapy. (PMID:28443471)
• the results of the present study are consistent with the hypothesis that miR-590 may promote G401 cell proliferation via downregulation of it specific target gene, WT1 as miR-590 expression level increased in Wilms’ tumor tissues compared with normal kidney tissues. (PMID:28498419)
• miR-590 expression was markedly increased in periphery blood mononuclear cells (PBMC) and cerebrospinal fluid (CSF) of patients with multiple sclerosis, and positively correlated with the disease severity. (PMID:28947212)
• MicroRNA-590-5p regulates cell viability, apoptosis, migration and invasion of renal cell carcinoma cell lines through targeting ARHGAP24 (PMID:29019371)
• demonstrated that miR-590-3p regulates colon cancer progression via WIF1 and DKK1 (PMID:29164578)
• Data suggest that targeting of hypoxia-induced miR-590-5p may provide an effective therapeutic approach to inhibit colorectal cancer (CRC) progression. (PMID:29247825)
• Overexpression of miR-590 promoted cell proliferation and invasion capability of GC cells, while knockdown of miR-590 reversed these effects. (PMID:29473240)
• we demonstrated that CREB1 is a downstream target of miR-590-3p and UCA1 activates CREB1 expression by sponging to miR-590-3p. (PMID:29516678)
• Low miR590 expression is associated with breast cancer. (PMID:29534690)
• Mechanistically, MIR205HG depletes endogenous miR-590-3p leading to increased cyclin B, cdk1, and YAP protein expression. The findings identify a transcriptional and post-transcriptional molecular network that includes mutant p53 protein, lncMIR205HG, YAP, and other proliferation-related genes, which are enriched in head and neck squamous cell carcinoma patients with poor prognosis. (PMID:29556360)
• The present study identified that SEPT7 was a potential target of miR5903p and demonstrated that SEPT7 is associated with mediating the proapoptotic effect of miR5903p in human osteoblast cell line hFOB 1.19. (PMID:29568931)
• Low FOXA2/high VCAN levels mediate the tumor-promoting effects of miR-590-3p. (PMID:29748371)
• The miR-590-5p/YAP axis may be an important novel mechanism in the pathogenesis of CD and colorectal cancer. (PMID:29912317)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.