MIR591

Summary

MIR591 (microRNA 591, HGNC:32847) is a microRNA gene on chromosome 7q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693176 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32847
Approved symbol	MIR591
Name	microRNA 591
Location	7q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-591
Ensembl gene	ENSG00000208025
Ensembl biotype	miRNA
Entrez	693176
RNAcentral	URS000075D670 — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385290

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385290 — 1 exons

Exon	Start	End
ENSE00001500296	96219662	96219756

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 87.64.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	87.64	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.67	gold quality
corpus callosum	UBERON:0002336	82.85	gold quality
kidney	UBERON:0002113	82.60	gold quality
blood	UBERON:0000178	82.20	gold quality
calcaneal tendon	UBERON:0003701	82.15	gold quality
liver	UBERON:0002107	81.94	gold quality
adrenal tissue	UBERON:0018303	81.68	gold quality
stomach	UBERON:0000945	77.66	gold quality
heart	UBERON:0000948	76.88	gold quality
monocyte	CL:0000576	76.28	gold quality
adrenal gland	UBERON:0002369	75.84	gold quality
intestine	UBERON:0000160	74.89	gold quality
adult mammalian kidney	UBERON:0000082	72.64	gold quality
gastrocnemius	UBERON:0001388	72.37	gold quality
lung	UBERON:0002048	71.95	gold quality
body of pancreas	UBERON:0001150	71.73	gold quality
prefrontal cortex	UBERON:0000451	71.49	gold quality
heart left ventricle	UBERON:0002084	71.48	gold quality
right atrium auricular region	UBERON:0006631	71.26	gold quality
endometrium	UBERON:0001295	71.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.73	gold quality
body of stomach	UBERON:0001161	69.51	gold quality
urinary bladder	UBERON:0001255	69.19	gold quality
tibial artery	UBERON:0007610	68.27	gold quality
Ammon’s horn	UBERON:0001954	68.11	gold quality
descending thoracic aorta	UBERON:0002345	67.73	gold quality
colon	UBERON:0001155	67.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.25	gold quality
transverse colon	UBERON:0001157	66.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• MiR-106a and miR-591 have important roles in conferring Paclitaxel resistance to ovarian cancer cells. (PMID:23807165)
• Hsa_circ_0069094 accelerates cell malignancy and glycolysis through regulating the miR-591/HK2 axis in breast cancer. (PMID:33309838)
• Knockdown of Circ_SLC39A8 protects against the progression of osteoarthritis by regulating miR-591/IRAK3 axis. (PMID:33658057)
• CircABCC1 promotes the development of glioma by sponging miR-591 and modulating high-mobility group A2. (PMID:35000195)
• Silencing circular RNA hsa_circABCC1 inhibits osteosarcoma progression through down-regulating HDAC4 via sponging miR-591. (PMID:37052456)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.