MIR593

Summary

MIR593 (microRNA 593, HGNC:32849) is a microRNA gene on chromosome 7q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693178 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32849
Approved symbol	MIR593
Name	microRNA 593
Location	7q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-593
Ensembl gene	ENSG00000207588
Ensembl biotype	miRNA
Entrez	693178
RNAcentral	URS000052FD62 — miRNA, 100 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384856

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384856 — 1 exons

Exon	Start	End
ENSE00001499863	128081861	128081960

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 92.94.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.94	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	91.43	gold quality
bone marrow	UBERON:0002371	83.55	gold quality
adrenal tissue	UBERON:0018303	82.09	gold quality
right lung	UBERON:0002167	79.91	gold quality
ectocervix	UBERON:0012249	78.69	gold quality
blood	UBERON:0000178	78.29	gold quality
duodenum	UBERON:0002114	77.62	gold quality
body of pancreas	UBERON:0001150	76.91	gold quality
pancreas	UBERON:0001264	76.65	gold quality
monocyte	CL:0000576	76.64	gold quality
calcaneal tendon	UBERON:0003701	76.47	gold quality
placenta	UBERON:0001987	75.57	gold quality
stomach	UBERON:0000945	75.49	gold quality
body of stomach	UBERON:0001161	75.08	gold quality
skin of abdomen	UBERON:0001416	75.03	gold quality
islet of Langerhans	UBERON:0000006	74.92	gold quality
ascending aorta	UBERON:0001496	74.90	gold quality
zone of skin	UBERON:0000014	74.56	gold quality
skin of leg	UBERON:0001511	74.30	gold quality
thoracic aorta	UBERON:0001515	74.28	gold quality
mucosa of stomach	UBERON:0001199	74.13	gold quality
muscle of leg	UBERON:0001383	74.08	gold quality
endometrium	UBERON:0001295	74.00	gold quality
gastrocnemius	UBERON:0001388	73.82	gold quality
heart	UBERON:0000948	73.67	gold quality
myometrium	UBERON:0001296	73.63	gold quality
left ovary	UBERON:0002119	73.60	gold quality
body of uterus	UBERON:0009853	73.53	gold quality
heart left ventricle	UBERON:0002084	73.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• PLK1 is post-transcriptionally regulated by miR-593* and could be a promising molecular target for EC treatment. (PMID:21170987)
• The various levels of specific miRNAs, particularly miR-593 and miR-511 whose direct target is the PROP1 gene, may serve as a non-invasive diagnostic biomarkers for children with CPHD. (PMID:25434367)
• miR-593 serum levels were significantly elevated in patients with obesity and obese patients with type 2 diabetes (PMID:25912229)
• Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC). (PMID:25912308)
• this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis. (PMID:27613819)
• LINC02163 regulates growth and epithelial-to-mesenchymal transition phenotype via miR-593-3p/FOXK1 axis in gastric cancer cells (PMID:29893595)
• The findings suggest an oncogenic role for hsa_circ_0007534 in breast cancer by acting as a miR-593 sponge to promote MUC19 expression. (PMID:30139516)
• miR-593 inhibits the proliferation of colon cancer cells by down-regulating PLK1 and plays the role as a tumor suppressor in colon cancer. (PMID:30890500)
• Long noncoding RNA ENST00000413528 sponges microRNA-593-5p to modulate human glioma growth via polo-like kinase 1. (PMID:30924320)
• MiR-593-5p promotes the development of hypoxic-induced pulmonary hypertension via targeting PLK1. (PMID:31081105)
• miR-593-5p inhibit cell proliferation by targeting PLK1 in non small cell lung cancer cells. (PMID:31864714)
• MiR-593-5p inhibited proliferation and migration of lung adenocarcinoma by targeting ICAM-1. (PMID:32373966)
• Overexpression of hsa_circ_0136666 predicts poor prognosis and initiates osteosarcoma tumorigenesis through miR-593-3p/ZEB2 pathway. (PMID:32424109)
• Regulatory roles of miR-593 in the proliferation and invasion of human hepatic carcinoma. (PMID:32633355)
• MicroRNA-593-3p Expression in Peritoneal Lavage Fluid as a Prognostic Marker for Pancreatic Cancer Patients Undergoing Staging Laparoscopy. (PMID:33393045)
• lncRNA TUG1 promotes the development of oral squamous cell carcinoma by regulating the MAPK signaling pathway by sponging miR-593-3p. (PMID:35604743)
• Hsa_circ_0001535 inhibits the proliferation and migration of ovarian cancer by sponging miR-593-3p, upregulating PTEN expression. (PMID:37000289)
• MicroRNA-593-5p contributes to cell death following exposure to 1-methyl-4-phenylpyridinium by targeting PTEN-induced putative kinase 1. (PMID:37060996)
• Circ_0087851 suppresses colorectal cancer malignant progression through triggering miR-593-3p/BAP1-mediated ferroptosis. (PMID:38642144)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.