MIR595

Summary

MIR595 (microRNA 595, HGNC:32851) is a microRNA gene on chromosome 7q36.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693180 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32851
Approved symbol	MIR595
Name	microRNA 595
Location	7q36.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-595
Ensembl gene	ENSG00000207637
Ensembl biotype	miRNA
Entrez	693180
RNAcentral	URS000075B3FD — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384905

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384905 — 1 exons

Exon	Start	End
ENSE00001499912	158532718	158532813

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 82.34.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	82.34	gold quality
blood	UBERON:0000178	78.88	gold quality
corpus callosum	UBERON:0002336	76.63	gold quality
stomach	UBERON:0000945	74.11	gold quality
islet of Langerhans	UBERON:0000006	73.33	gold quality
kidney	UBERON:0002113	72.67	gold quality
Ammon’s horn	UBERON:0001954	72.08	gold quality
left adrenal gland cortex	UBERON:0035825	71.69	gold quality
body of pancreas	UBERON:0001150	71.24	gold quality
ascending aorta	UBERON:0001496	70.91	gold quality
left adrenal gland	UBERON:0001234	70.65	gold quality
body of stomach	UBERON:0001161	70.39	gold quality
endometrium	UBERON:0001295	70.14	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.13	gold quality
lung	UBERON:0002048	69.33	gold quality
minor salivary gland	UBERON:0001830	68.35	gold quality
skin of abdomen	UBERON:0001416	68.17	gold quality
skin of leg	UBERON:0001511	67.83	gold quality
myometrium	UBERON:0001296	67.58	gold quality
transverse colon	UBERON:0001157	66.74	gold quality
putamen	UBERON:0001874	66.73	gold quality
intestine	UBERON:0000160	66.64	gold quality
colon	UBERON:0001155	66.37	gold quality
body of uterus	UBERON:0009853	65.84	gold quality
amygdala	UBERON:0001876	65.48	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.39	gold quality
pituitary gland	UBERON:0000007	65.34	gold quality
ectocervix	UBERON:0012249	65.23	gold quality
prostate gland	UBERON:0002367	65.11	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Overexpression of miR-595 in the sera is associated with active forms of inflammatory bowel disease. (PMID:25628040)
• ULK1 could inhibit p70S6K in starvation-induced autophagy, and further identified that miR-4487 and miR-595 were novel ULK1 target miRNAs (PMID:26183158)
• miR-595 played a critical role in carcinogenesis by suppression of SOX7. (PMID:27133048)
• Authors show that miR-595 expression appears significantly downregulated in the majority of primary samples derived from MDS patients with (-7)/(7q-), in association with RPL27A upregulation. (PMID:27374104)
• miR-595 was downregulated in epithelial ovarian cancer tissues in comparison with noncancerous ovarian tissues (PMID:29077170)
• miR-595 acts as a phenotypic regulator of methotrexate sensitivity in CEM/C1 cells by targeting SLC19A1. (PMID:29345051)
• results revealed that the three RNAs-based biomarker network (long non-coding intergenic RNA-[lncRNA RP11-909B2.1], Homo sapiens microRNA-595 [hsa-miRNA-595], and L3MBTL1 mRNA), had high sensitivity and specificity for discriminating CRC from healthy controls and also from benign colorectal neoplasm. (PMID:29737552)
• miR-595 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting NF-kappaB signalling pathway. (PMID:32107085)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.