MIR596

Summary

MIR596 (microRNA 596, HGNC:32852) is a microRNA gene on chromosome 8p23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693181 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32852
Approved symbol	MIR596
Name	microRNA 596
Location	8p23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-596
Ensembl gene	ENSG00000207826
Ensembl biotype	miRNA
Entrez	693181
RNAcentral	URS000075AC80 — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385091

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385091 — 1 exons

Exon	Start	End
ENSE00001500097	1817231	1817307

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 96.14.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.14	gold quality
lymph node	UBERON:0000029	80.77	gold quality
kidney	UBERON:0002113	77.00	gold quality
monocyte	CL:0000576	75.19	gold quality
gastrocnemius	UBERON:0001388	72.53	gold quality
blood	UBERON:0000178	71.35	gold quality
heart left ventricle	UBERON:0002084	71.00	gold quality
stomach	UBERON:0000945	70.88	gold quality
heart	UBERON:0000948	70.21	gold quality
ascending aorta	UBERON:0001496	70.01	gold quality
body of stomach	UBERON:0001161	69.82	gold quality
right atrium auricular region	UBERON:0006631	68.33	gold quality
right lung	UBERON:0002167	68.22	gold quality
body of pancreas	UBERON:0001150	67.93	gold quality
endometrium	UBERON:0001295	67.76	gold quality
tibial artery	UBERON:0007610	67.44	gold quality
transverse colon	UBERON:0001157	66.62	gold quality
rectum	UBERON:0001052	66.54	gold quality
minor salivary gland	UBERON:0001830	66.25	gold quality
substantia nigra	UBERON:0002038	65.95	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.90	gold quality
nucleus accumbens	UBERON:0001882	65.88	gold quality
anterior cingulate cortex	UBERON:0009835	65.29	gold quality
putamen	UBERON:0001874	65.15	gold quality
Ammon’s horn	UBERON:0001954	65.15	gold quality
thoracic mammary gland	UBERON:0005200	65.01	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.86	gold quality
myometrium	UBERON:0001296	64.81	gold quality
vagina	UBERON:0000996	64.74	gold quality
cerebral cortex	UBERON:0000956	64.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• MIR596 is frequently observed in oral squamous cell carcinoma and regulates expression of LGAL3BP. (PMID:23233740)
• findings may help clarify the molecular mechanism of the tumor-suppressive effect through down-regulation of LGALS3BP by miR-596 in Oral Squamous Cell Carcinoma (PMID:26502662)
• Among the hits, miR-596 was identified as a regulator of p53. The overexpression of miR-596 significantly increased p53 at the protein level, thereby inducing apoptosis. (PMID:28732184)
• miR-596 overexpression effectively inhibited MAPK/ERK signaling, cell proliferation, migration, and invasion and increased the cell apoptosis of melanoma cells. In addition, we found that miR-596 directly targets MEK1 and two apoptotic proteins, MCL1, and BCL2L1, in melanoma cells (PMID:29183729)
• MiR-596 has a tumor suppressive role in gastric cancer and is downregulated partly due to promoter hypermethylation. Furthermore, PRDX1 is one of the putative target genes of miR-596. (PMID:30886505)
• these results demonstrate that CREPT exerts an oncogenic role in glioma and its expression is regulated by miR-596. (PMID:30995540)
• RHPN1-AS1 Drives the Progression of Hepatocellular Carcinoma via Regulating miR-596/IGF2BP2 Axis. (PMID:31692433)
• MiR-596 inhibits osteoblastic differentiation and cell proliferation by targeting Smad3 in steroid-induced osteonecrosis of femoral head. (PMID:32410637)
• MicroRNA-596 is epigenetically inactivated and suppresses prostatic cancer cell growth and migration via regulating Wnt/beta-catenin signaling. (PMID:33387246)
• Plasma exosomal miR-596: a novel biomarker predicts survival in patients with idiopathic pulmonary artery hypertension. (PMID:33788649)
• Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-kappaB activating protein. (PMID:36206097)
• [LncRNA LINC00342 regulates gastric cancer cell proliferation, migration and invasion by targeting miR-596]. (PMID:37933652)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.