MIR597

Summary

MIR597 (microRNA 597, HGNC:32853) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693182 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32853
Approved symbol	MIR597
Name	microRNA 597
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-597
Ensembl gene	ENSG00000207701
Ensembl biotype	miRNA
Entrez	693182
RNAcentral	URS000072B4C8 — miRNA, 97 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384968

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384968 — 1 exons

Exon	Start	End
ENSE00001499975	9741672	9741768

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 83.48.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.48	gold quality
right uterine tube	UBERON:0001302	83.01	gold quality
adrenal tissue	UBERON:0018303	79.40	gold quality
blood	UBERON:0000178	78.61	gold quality
corpus callosum	UBERON:0002336	78.51	gold quality
calcaneal tendon	UBERON:0003701	78.24	gold quality
endocervix	UBERON:0000458	77.94	gold quality
kidney	UBERON:0002113	77.52	gold quality
body of pancreas	UBERON:0001150	77.42	gold quality
bone marrow	UBERON:0002371	77.42	gold quality
liver	UBERON:0002107	76.23	gold quality
monocyte	CL:0000576	76.15	gold quality
islet of Langerhans	UBERON:0000006	75.05	gold quality
adult mammalian kidney	UBERON:0000082	74.04	gold quality
stomach	UBERON:0000945	73.39	gold quality
endometrium	UBERON:0001295	73.33	gold quality
gastrocnemius	UBERON:0001388	72.87	gold quality
urinary bladder	UBERON:0001255	72.30	gold quality
left adrenal gland	UBERON:0001234	70.51	gold quality
heart	UBERON:0000948	70.38	gold quality
fallopian tube	UBERON:0003889	70.20	gold quality
body of stomach	UBERON:0001161	69.98	gold quality
intestine	UBERON:0000160	69.38	gold quality
ascending aorta	UBERON:0001496	69.19	gold quality
tibial artery	UBERON:0007610	69.14	gold quality
anterior cingulate cortex	UBERON:0009835	69.13	gold quality
ectocervix	UBERON:0012249	69.10	gold quality
right atrium auricular region	UBERON:0006631	68.78	gold quality
left uterine tube	UBERON:0001303	68.76	gold quality
lung	UBERON:0002048	68.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• MiR-597 acts as a tumor suppressor in breast cancer cells by the down-regulation of FOSL2.miR-597 inhibits breast cancer cell proliferation, migration and invasion through FOSL2. (PMID:28393251)
• MiR-597 could reduce the expression of 14-3-3sigma to drive EMT, and promote the growth and enhanced migration and invasion of nasopharyngeal carcinoma. (PMID:30569880)
• circ101555 might function as a competing endogenous RNA of miR-597-5p to up-regulate CDK6 and RPA3 expression in colorectal cancer. (PMID:31300733)
• MicroRNA-597 inhibits NSCLC progression through negatively regulating CDK2 expression. (PMID:32373965)
• miR-597-5p inhibits cell growth and promotes cell apoptosis by targeting ELK1 in pancreatic cancer. (PMID:32613573)
• Silencing circRNA_001937 may inhibit cutaneous squamous cell carcinoma proliferation and induce apoptosis by preventing the sponging of the miRNA5973p/FOSL2 pathway. (PMID:33000177)
• LncRNA GSTM3TV2 Promotes Cell Proliferation and Invasion via miR-597/FOSL2 Axis in Hepatocellular Carcinoma. (PMID:34458365)
• MiR-597-5p suppresses the progression of hepatocellular carcinoma via targeting transcriptional enhancer associate domain transcription factor 1 (TEAD1). (PMID:35169903)
• Upregulation of microRNA-597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition. (PMID:36018564)
• Proximal tubular MBD2 promotes autophagy to drive the progression of AKI caused by vancomycin via regulation of miR-597-5p/S1PR1 axis. (PMID:38578557)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.