MIR598

Summary

MIR598 (microRNA 598, HGNC:32854) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693183 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32854
Approved symbol	MIR598
Name	microRNA 598
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-598
Ensembl gene	ENSG00000207600
Ensembl biotype	miRNA
Entrez	693183
RNAcentral	URS0000669010 — miRNA, 97 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384868

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384868 — 1 exons

Exon	Start	End
ENSE00001499875	11035206	11035302

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 78.78.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.78	gold quality
duodenum	UBERON:0002114	78.12	gold quality
lymph node	UBERON:0000029	75.68	gold quality
blood	UBERON:0000178	74.30	gold quality
adult mammalian kidney	UBERON:0000082	73.40	gold quality
gastrocnemius	UBERON:0001388	73.18	gold quality
islet of Langerhans	UBERON:0000006	72.87	gold quality
body of pancreas	UBERON:0001150	71.00	gold quality
body of stomach	UBERON:0001161	69.75	gold quality
heart left ventricle	UBERON:0002084	69.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.24	gold quality
tibial artery	UBERON:0007610	68.93	gold quality
endometrium	UBERON:0001295	68.80	gold quality
popliteal artery	UBERON:0002250	68.73	gold quality
descending thoracic aorta	UBERON:0002345	68.68	gold quality
adrenal gland	UBERON:0002369	68.67	gold quality
left adrenal gland	UBERON:0001234	68.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.21	gold quality
putamen	UBERON:0001874	68.12	gold quality
heart	UBERON:0000948	68.03	gold quality
thoracic aorta	UBERON:0001515	67.87	gold quality
esophagus	UBERON:0001043	67.81	gold quality
amygdala	UBERON:0001876	67.73	gold quality
substantia nigra	UBERON:0002038	67.73	gold quality
liver	UBERON:0002107	67.70	gold quality
ascending aorta	UBERON:0001496	67.67	gold quality
esophagus mucosa	UBERON:0002469	67.55	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.29	gold quality
right ovary	UBERON:0002118	67.20	gold quality
right adrenal gland	UBERON:0001233	67.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Low miR598 expression is associated with metastasis in colorectal cancer. (PMID:28161537)
• High miR598 expression is associated with Invasive Pituitary Adenomas. (PMID:28315020)
• findings enrich the knowledge of miR-598 in osteosarcoma progression. (PMID:28882648)
• miR598 contributed to cell proliferation and cell cycle progression in colorectal carcinoma by targeting INPP5E. (PMID:29257251)
• High miR598 expression is associated with ulcerative colitis as compared to Crohn’s colitis. (PMID:29272478)
• In this study, authors found that miRNA-598 (miR-598) expression was significantly downregulated in GBM tissues and cell lines. Restoring miR-598 expression inhibited cell proliferation and invasion in GBM. (PMID:29444745)
• These findings for the first time revealed that miR-598, as a tumor suppressor, negatively regulate DERL1 and Epithelial-Mesenchymal Transition to suppress the invasion and migration in Non-Small Cell Lung Cancer (NSCLC), thereby putatively serving as a novel therapeutic target for NSCLC clinical treatment. (PMID:29768262)
• LINC01296/miR-598/Twist1 constitutes a positive feedback loop to promote the tumorigenesis of non-small cell lung cancer. (PMID:30240003)
• MicroRNA-598 acts as an inhibitor in retinoblastoma through targeting E2F1 and regulating AKT pathway. (PMID:31674056)
• circCELSR1 facilitates ovarian cancer proliferation and metastasis by sponging miR-598 to activate BRD4 signals. (PMID:32640974)
• CircB3GNTL1 and miR-598 regulation effects on proliferation, apoptosis, and glutaminolysis in gastric cancer cells. (PMID:33287917)
• Circ_0007580 knockdown strengthens the radiosensitivity of non-small cell lung cancer via the miR-598-dependent regulation of THBS2. (PMID:35044104)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir598	ENSMUSG00000076049
rattus_norvegicus	Mir598	ENSRNOG00000067234

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.