MIR599

Summary

MIR599 (microRNA 599, HGNC:32855) is a microRNA gene on chromosome 8q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693184 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32855
Approved symbol	MIR599
Name	microRNA 599
Location	8q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-599
Ensembl gene	ENSG00000207804
Ensembl biotype	miRNA
Entrez	693184
RNAcentral	URS0000728487 — miRNA, 95 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385069

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385069 — 1 exons

Exon	Start	End
ENSE00001500075	99536636	99536730

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 84.97.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	84.97	gold quality
adult mammalian kidney	UBERON:0000082	82.49	gold quality
adrenal tissue	UBERON:0018303	80.51	gold quality
blood	UBERON:0000178	80.38	gold quality
bone marrow	UBERON:0002371	78.68	gold quality
stomach	UBERON:0000945	77.36	gold quality
liver	UBERON:0002107	76.99	gold quality
endometrium	UBERON:0001295	76.79	gold quality
heart	UBERON:0000948	75.91	gold quality
anterior cingulate cortex	UBERON:0009835	75.87	gold quality
ectocervix	UBERON:0012249	75.58	gold quality
gastrocnemius	UBERON:0001388	73.76	gold quality
calcaneal tendon	UBERON:0003701	73.54	gold quality
intestine	UBERON:0000160	71.00	gold quality
putamen	UBERON:0001874	70.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.56	gold quality
colon	UBERON:0001155	69.45	gold quality
body of pancreas	UBERON:0001150	68.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.41	gold quality
tibial artery	UBERON:0007610	67.91	gold quality
lung	UBERON:0002048	67.77	gold quality
right coronary artery	UBERON:0001625	67.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.65	gold quality
body of stomach	UBERON:0001161	67.60	gold quality
ascending aorta	UBERON:0001496	67.18	gold quality
left coronary artery	UBERON:0001626	66.56	gold quality
transverse colon	UBERON:0001157	66.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.51	gold quality
left ovary	UBERON:0002119	65.49	gold quality
right frontal lobe	UBERON:0002810	65.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Expression of microRNA-599 was downregulated and LRRK2 expression was upregulated in MPP+-induced human SH-SY5Y cells - model for secondary Parkinson disease (PD). Binding condition between microRNA-599 and LRRK2 were verified. The microRNA-599 overexpression downregulated the LRRK2 expression in SH-SY5Y cells. MicroRNA-599 inhibits the development of PD through regulating the LRRK2 expression. (PMID:30720180)
• Serum miR-599 may be used as a molecular marker in the diagnosis of ischemic stroke and may play an important role in the pathogenesis and development of ischemic stroke. (PMID:31307174)
• microRNA-599 promotes apoptosis and represses proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells via downregulation of Hey2-depentent Notch signaling pathway. (PMID:31565805)
• Hsa_circ_0000285 functions as a competitive endogenous RNA to promote osteosarcoma progression by sponging hsa-miRNA-599. (PMID:31784675)
• MiR-599 regulates LPS-mediated apoptosis and inflammatory responses through the JAK2/STAT3 signalling pathway via targeting ROCK1 in human umbilical vein endothelial cells. (PMID:32248560)
• Circular RNA circANKRD36 regulates Casz1 by targeting miR-599 to prevent osteoarthritis chondrocyte apoptosis and inflammation. (PMID:33205602)
• Effects of miR-599 targeting YAP1 on proliferation, invasion and apoptosis of bladder urothelial carcinoma cells. (PMID:33359177)
• MiR-599 targeting TOP2A inhibits the malignancy of bladder cancer cells. (PMID:34284141)
• Hsa-miR-599 inhibits breast cancer progression via BRD4/Jagged1/Notch1 axis. (PMID:34415065)
• eIF4A3-induced circWAC promotes breast cancer progression through mediating miR-599/E2F3 axis. (PMID:34989110)
• Mechanism of CircANKRD36 regulating cell heterogeneity and endothelial mesenchymal transition in aortic valve stromal cells by regulating miR-599 and TGF-beta signaling pathway. (PMID:35074490)
• Downregulation of miR-599 predicts poor outcome in cervical cancer patients and promotes the progression of cervical cancer. (PMID:35361384)
• Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates in the Pathogenesis of Abdominal Aortic Aneurysm by Regulating the Functions of Vascular Smooth Muscle Cells. (PMID:37094862)
• MicroRNA-599-Regulated Susceptibility to Acute Kidney Injury in Patients with Cirrhosis is Mediated by the Sirtuin 1 (SIRT1) rs4746720 Single Nucleotide Polymorphism. (PMID:38062807)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.