MIR600

Summary

MIR600 (microRNA 600, HGNC:32856) is a microRNA gene on chromosome 9q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693185 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32856
Approved symbol	MIR600
Name	microRNA 600
Location	9q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-600
Ensembl gene	ENSG00000283941
Ensembl biotype	miRNA
Entrez	693185
RNAcentral	URS0000759FE6 — miRNA, 98 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385007

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385007 — 1 exons

Exon	Start	End
ENSE00001500014	123111546	123111643

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 80.83.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	80.83	gold quality
anterior cingulate cortex	UBERON:0009835	77.09	gold quality
nucleus accumbens	UBERON:0001882	74.83	gold quality
islet of Langerhans	UBERON:0000006	72.57	gold quality
muscle of leg	UBERON:0001383	70.60	gold quality
heart left ventricle	UBERON:0002084	69.77	gold quality
tibial artery	UBERON:0007610	67.45	gold quality
gastrocnemius	UBERON:0001388	67.09	gold quality
ectocervix	UBERON:0012249	66.29	gold quality
blood	UBERON:0000178	65.27	gold quality
body of stomach	UBERON:0001161	63.36	gold quality
right coronary artery	UBERON:0001625	63.31	gold quality
transverse colon	UBERON:0001157	63.01	gold quality
left coronary artery	UBERON:0001626	62.96	gold quality
right adrenal gland	UBERON:0001233	62.63	gold quality
thoracic aorta	UBERON:0001515	62.39	gold quality
ascending aorta	UBERON:0001496	62.20	gold quality
right adrenal gland cortex	UBERON:0035827	61.66	gold quality
skin of leg	UBERON:0001511	61.45	gold quality
left adrenal gland cortex	UBERON:0035825	61.44	gold quality
liver	UBERON:0002107	61.09	gold quality
left adrenal gland	UBERON:0001234	59.82	gold quality
thoracic mammary gland	UBERON:0005200	59.60	gold quality
body of pancreas	UBERON:0001150	58.75	gold quality
tibial nerve	UBERON:0001323	58.53	gold quality
esophagus mucosa	UBERON:0002469	58.18	gold quality
colon	UBERON:0001155	57.65	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.30	gold quality
upper lobe of left lung	UBERON:0008952	57.28	gold quality
omental fat pad	UBERON:0010414	56.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Integrative miRNA analysis identified hsa-miR-600 significantly associated with prolonged survival time of patients with cervical neoplasm. This miRNA is a potential prognostic target for cervical cancer. (PMID:28771797)
• the hsa_circ_0071589/miR-600/EZH2 axis may play critical regulatory roles in the pathogenesis of colorectal cancer. (PMID:29710537)
• Circular RNA circPIP5K1A promotes non-small cell lung cancer proliferation and metastasis through miR-600/HIF-1alpha regulation. (PMID:31241217)
• [MiR-600 suppresses HeLa cell proliferation by inhibiting hypoxia-inducible factor-1alpha signaling pathway]. (PMID:33624593)
• FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma. (PMID:34416910)
• miR-600 promotes ovarian cancer cells stemness, proliferation and metastasis via targeting KLF9. (PMID:35501825)
• MiR-600 mediates EZH2/RUNX3 signal axis to modulate breast cancer cell viability and sorafenib sensitivity. (PMID:38229326)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.