MIR601

Summary

MIR601 (microRNA 601, HGNC:32857) is a microRNA gene on chromosome 9q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693186 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32857
Approved symbol	MIR601
Name	microRNA 601
Location	9q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-601
Ensembl gene	ENSG00000207991
Ensembl biotype	miRNA
Entrez	693186
RNAcentral	URS0000725398 — miRNA, 79 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385256

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385256 — 1 exons

Exon	Start	End
ENSE00001500262	123402525	123402603

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 95.76.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.76	gold quality
bone marrow	UBERON:0002371	84.81	gold quality
calcaneal tendon	UBERON:0003701	84.55	gold quality
adrenal tissue	UBERON:0018303	79.06	gold quality
blood	UBERON:0000178	78.90	gold quality
monocyte	CL:0000576	77.10	gold quality
endocervix	UBERON:0000458	75.66	gold quality
apex of heart	UBERON:0002098	73.68	gold quality
gastrocnemius	UBERON:0001388	72.37	gold quality
stomach	UBERON:0000945	71.97	gold quality
kidney	UBERON:0002113	71.45	gold quality
fundus of stomach	UBERON:0001160	71.34	gold quality
heart	UBERON:0000948	71.16	gold quality
lower esophagus mucosa	UBERON:0035834	71.07	gold quality
liver	UBERON:0002107	70.73	gold quality
heart left ventricle	UBERON:0002084	70.72	gold quality
adult mammalian kidney	UBERON:0000082	70.56	gold quality
right atrium auricular region	UBERON:0006631	70.32	gold quality
endometrium	UBERON:0001295	70.10	gold quality
ectocervix	UBERON:0012249	69.76	gold quality
right adrenal gland cortex	UBERON:0035827	69.68	gold quality
smooth muscle tissue	UBERON:0001135	69.51	gold quality
corpus callosum	UBERON:0002336	69.05	gold quality
right lobe of liver	UBERON:0001114	68.92	gold quality
body of stomach	UBERON:0001161	68.79	gold quality
body of pancreas	UBERON:0001150	68.48	gold quality
lung	UBERON:0002048	68.36	gold quality
myometrium	UBERON:0001296	67.93	gold quality
tibial artery	UBERON:0007610	67.57	gold quality
Ammon’s horn	UBERON:0001954	67.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• effect of hsa-miR-601 on gene expression changes in human lung cancer cells A549: findings suggest that hsa-miR-601 could affect a variety of signaling pathways accompanying orchestrated gene expression changes (PMID:19889580)
• Plasma miR-601 and miR-760 can potentially serve as promising non-invasive biomarkers for the early detection of colorectal cancer. (PMID:22970209)
• miR-601 inhibits growth and invasion of breast cancer cells by targeting PTP4A1. (PMID:27044835)
• overexpression of SIRT1 could reverse the effect of miR-601 on pancreatic cancer cells; miR-601 suppresses pancreatic cancer cell proliferation and migration (PMID:27993677)
• MiR-601 suppressed the proliferation, invasion and migration of esophagus carcinoma cells by down-regulating HDAC6 expression. (PMID:30779074)
• miR-601 activates Nrf2 signaling to protect retinal pigment epithelial cells from H2O2 by targeting Cul3 (PMID:31178131)
• The expression level of miR-601 is dramatically up-regulated in gastric cancer (PMID:31547835)
• Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1. (PMID:33955831)
• MiR-601 Promotes Cell Proliferation of Human Glioblastoma Cells by Suppressing TINP1 Expression. (PMID:35139491)
• Identification of miR-106b-5p, miR-601, and miR-760 Expression and Their Clinical Values in Non-Small Cell Lung Cancer (NSCLC) Patients’ Serum. (PMID:37429174)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.