MIR602

Summary

MIR602 (microRNA 602, HGNC:32858) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693187 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32858
Approved symbol	MIR602
Name	microRNA 602
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-602
Ensembl gene	ENSG00000207693
Ensembl biotype	miRNA
Entrez	693187
RNAcentral	URS000075B5BC — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384960

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384960 — 1 exons

Exon	Start	End
ENSE00001499967	137838419	137838516

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 79.19.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	79.19	gold quality
monocyte	CL:0000576	77.25	gold quality
liver	UBERON:0002107	74.01	gold quality
gastrocnemius	UBERON:0001388	73.62	gold quality
right lobe of liver	UBERON:0001114	73.20	gold quality
heart left ventricle	UBERON:0002084	72.40	gold quality
body of pancreas	UBERON:0001150	71.19	gold quality
tibial artery	UBERON:0007610	71.00	gold quality
heart	UBERON:0000948	70.64	gold quality
body of stomach	UBERON:0001161	70.51	gold quality
blood	UBERON:0000178	70.39	gold quality
stomach	UBERON:0000945	70.34	gold quality
endometrium	UBERON:0001295	70.12	gold quality
left uterine tube	UBERON:0001303	69.40	gold quality
left coronary artery	UBERON:0001626	69.30	gold quality
right adrenal gland	UBERON:0001233	69.21	gold quality
left adrenal gland	UBERON:0001234	69.03	gold quality
left adrenal gland cortex	UBERON:0035825	69.03	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.82	gold quality
right atrium auricular region	UBERON:0006631	68.76	gold quality
substantia nigra	UBERON:0002038	68.64	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.27	gold quality
ascending aorta	UBERON:0001496	68.20	gold quality
granulocyte	CL:0000094	68.18	gold quality
putamen	UBERON:0001874	68.17	gold quality
prefrontal cortex	UBERON:0000451	68.05	gold quality
endocervix	UBERON:0000458	68.03	gold quality
adult mammalian kidney	UBERON:0000082	67.97	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.65	gold quality
right ovary	UBERON:0002118	67.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• MicroRNA-602 plays a pro-carcinogenic role in HBV-related hepatocarcinogenesis by inhibiting RASSF1A. (PMID:20364114)
• MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes. (PMID:25385442)
• Study found that miR-602 was significantly upregulated its promotor hypomethylated in esophageal squamous cell carcinoma (ESCC). Its overexpression was closely related to lymph node metastasis and TNM stages and short overall. These results implied that miR-602 may act as a tumor oncogene, which might provide a possibility to predict ESCC progression. (PMID:31401147)
• The elevation of S100B and downregulation of circulating miR-602 in the sera of ischemic stroke (IS) patients: the emergence of novel diagnostic and prognostic markers. (PMID:32166472)
• Upregulation of lncRNA HITT promotes cell apoptosis by suppressing the maturation of miR-602 in gastric cancer. (PMID:35852131)
• miR-602 Activates NRF2 Antioxidant Pathways to Protect HBMECs from OGD/R-Induced Oxidative Stress via Targeting KEAP1 and HRD1. (PMID:36193504)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.