MIR603

Summary

MIR603 (microRNA 603, HGNC:32859) is a microRNA gene on chromosome 10p12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693188 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32859
Approved symbol	MIR603
Name	microRNA 603
Location	10p12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-603
Ensembl gene	ENSG00000207930
Ensembl biotype	miRNA
Entrez	693188
RNAcentral	URS00000EBE00 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385195

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385195 — 1 exons

Exon	Start	End
ENSE00001500201	24275685	24275781

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 84.81.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	84.81	gold quality
caudate nucleus	UBERON:0001873	82.94	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.74	gold quality
monocyte	CL:0000576	82.35	gold quality
islet of Langerhans	UBERON:0000006	81.15	gold quality
adrenal tissue	UBERON:0018303	80.12	gold quality
stomach	UBERON:0000945	79.77	gold quality
blood	UBERON:0000178	78.65	gold quality
adult mammalian kidney	UBERON:0000082	74.85	gold quality
calcaneal tendon	UBERON:0003701	74.77	gold quality
gastrocnemius	UBERON:0001388	74.76	gold quality
heart	UBERON:0000948	73.19	gold quality
liver	UBERON:0002107	73.04	gold quality
body of pancreas	UBERON:0001150	71.76	gold quality
intestine	UBERON:0000160	71.36	gold quality
Ammon’s horn	UBERON:0001954	70.93	gold quality
left adrenal gland	UBERON:0001234	70.80	gold quality
lung	UBERON:0002048	70.22	gold quality
body of stomach	UBERON:0001161	68.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.48	gold quality
endometrium	UBERON:0001295	68.46	gold quality
right adrenal gland	UBERON:0001233	68.30	gold quality
heart left ventricle	UBERON:0002084	68.08	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.94	gold quality
body of uterus	UBERON:0009853	67.87	gold quality
esophagus mucosa	UBERON:0002469	67.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.81	gold quality
substantia nigra	UBERON:0002038	67.66	gold quality
right atrium auricular region	UBERON:0006631	67.12	gold quality
omental fat pad	UBERON:0010414	66.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.91

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• High miR-603 is associated with laryngeal squamous cell carcinoma. (PMID:23817697)
• miR-603 regulates glioma development via Wnt-beta-cateninn signaling pathway and its WIF1 and CTNNBIP1 targets. (PMID:25681036)
• The SNP rs6218 in IGF-1 3’-UTR, through disrupting the regulatory role of miR-603 in IGF-1 expression, might act as a gastric cancer tumorigenic factor. (PMID:26068646)
• Mir603 rs11014002 T allele might contribute to the decreased risk of breast cancer in a sample of Iranian population. (PMID:26718432)
• This work suggests that miR-603 may be a novel Alzheimer’s disease-relevant miRNA and that its rs11014002 single nucleotide polymorphism may serve as a protective factor (PMID:26856603)
• Reduction in BRCC2 expression induced by miR-603 was responsible for the enhanced colony formation and proliferative ability noted in the MG-63 and U2OS cells. (PMID:27035098)
• miR-603 is a tumor suppressor targeting HK2 in ovarian cancer and its low level may result from DNMT3A-mediated methylation. (PMID:30365936)
• Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas. (PMID:32361246)
• MicroRNA-603 Promotes Progression of Cutaneous Melanoma by Regulating TBX5. (PMID:35003317)
• miR-603 promotes cell proliferation and differentiation by targeting TrkB in acute promyelocytic leukemia. (PMID:37726492)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.