MIR604

Summary

MIR604 (microRNA 604, HGNC:32860) is a microRNA gene on chromosome 10p11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693189 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32860
Approved symbol	MIR604
Name	microRNA 604
Location	10p11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-604
Ensembl gene	ENSG00000207612
Ensembl biotype	miRNA
Entrez	693189
RNAcentral	URS0000664FAA — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384880

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384880 — 1 exons

Exon	Start	End
ENSE00001499887	29545004	29545097

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 85.10.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	85.10	gold quality
adrenal tissue	UBERON:0018303	83.13	gold quality
blood	UBERON:0000178	80.40	gold quality
calcaneal tendon	UBERON:0003701	80.25	gold quality
bone marrow	UBERON:0002371	79.45	gold quality
kidney	UBERON:0002113	78.79	gold quality
monocyte	CL:0000576	77.41	gold quality
stomach	UBERON:0000945	76.71	gold quality
adult mammalian kidney	UBERON:0000082	75.83	gold quality
liver	UBERON:0002107	75.20	gold quality
muscle of leg	UBERON:0001383	75.15	gold quality
gastrocnemius	UBERON:0001388	74.39	gold quality
urinary bladder	UBERON:0001255	73.69	gold quality
islet of Langerhans	UBERON:0000006	73.63	gold quality
heart	UBERON:0000948	73.46	gold quality
ascending aorta	UBERON:0001496	73.16	gold quality
thoracic aorta	UBERON:0001515	72.59	gold quality
left adrenal gland cortex	UBERON:0035825	72.24	gold quality
heart left ventricle	UBERON:0002084	72.19	gold quality
myometrium	UBERON:0001296	71.82	gold quality
endocervix	UBERON:0000458	71.63	gold quality
adrenal gland	UBERON:0002369	71.46	gold quality
popliteal artery	UBERON:0002250	71.34	gold quality
right atrium auricular region	UBERON:0006631	71.33	gold quality
tibial artery	UBERON:0007610	71.32	gold quality
endometrium	UBERON:0001295	71.14	gold quality
left coronary artery	UBERON:0001626	71.10	gold quality
intestine	UBERON:0000160	70.68	gold quality
pancreas	UBERON:0001264	70.65	gold quality
ectocervix	UBERON:0012249	70.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The T allele at miR-604 rs2368392 may be a risk allele for the chronicity of HBV infection, but may be a protective allele for the progression to HCC in chronic HBV carriers. (PMID:25408584)
• Genetic Polymorphisms in miR-604A>G, miR-938G>A, miR-1302-3C>T and the Risk of Idiopathic Recurrent Pregnancy Loss. (PMID:34200157)
• circ_0052184 Promotes Colorectal Cancer Progression via Targeting miR-604/HOXA9 Axis. (PMID:36065412)
• miR604A>G gene polymorphism is associated with recurrent pregnancy loss in Turkish women. (PMID:37729371)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.