MIR605

Summary

MIR605 (microRNA 605, HGNC:32861) is a microRNA gene on chromosome 10q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693190 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32861
Approved symbol	MIR605
Name	microRNA 605
Location	10q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-605
Ensembl gene	ENSG00000207813
Ensembl biotype	miRNA
Entrez	693190
RNAcentral	URS000075ABF4 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385078

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385078 — 1 exons

Exon	Start	End
ENSE00001500084	51299573	51299655

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 88.14.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	88.14	gold quality
kidney	UBERON:0002113	85.20	gold quality
adrenal tissue	UBERON:0018303	84.61	gold quality
liver	UBERON:0002107	80.55	gold quality
adult mammalian kidney	UBERON:0000082	79.61	gold quality
lung	UBERON:0002048	77.69	gold quality
nucleus accumbens	UBERON:0001882	77.07	gold quality
intestine	UBERON:0000160	76.23	gold quality
endometrium	UBERON:0001295	74.79	gold quality
heart	UBERON:0000948	73.41	gold quality
gastrocnemius	UBERON:0001388	73.27	gold quality
colon	UBERON:0001155	71.49	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.24	gold quality
blood	UBERON:0000178	70.65	gold quality
heart left ventricle	UBERON:0002084	69.73	gold quality
left adrenal gland	UBERON:0001234	69.53	gold quality
esophagus mucosa	UBERON:0002469	68.24	gold quality
vagina	UBERON:0000996	68.13	gold quality
transverse colon	UBERON:0001157	67.90	gold quality
right atrium auricular region	UBERON:0006631	67.88	gold quality
body of uterus	UBERON:0009853	67.72	gold quality
tibial artery	UBERON:0007610	67.18	gold quality
popliteal artery	UBERON:0002250	67.17	gold quality
left adrenal gland cortex	UBERON:0035825	67.16	gold quality
descending thoracic aorta	UBERON:0002345	66.35	gold quality
right adrenal gland	UBERON:0001233	66.24	gold quality
ascending aorta	UBERON:0001496	66.11	gold quality
left coronary artery	UBERON:0001626	65.60	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• MicroRNA miR-605 is transcriptionally activated by p53 interaction with its promotor region, and post-transcriptionally represses Mdm2. (PMID:21217645)
• There was no significant association of SNPs of miR-149 and miR-605 with lung cancer. (PMID:21671485)
• miR-605 AG/GG genotype carriers had increased susceptibilities to colorectal cancer and gastric cancer in smokers (PMID:21976437)
• Single-nucleotide polymorphism in MIRN605 is associated with biochemical recurrence in prostate cancer. (PMID:24740842)
• MiR-605 directly targets and represses PSMD10 expression. (PMID:25131931)
• Data indicate that the microRNA miR-605 SNP (rs2043556) modifies the age of cancer onset in Li-Fraumeni syndrome (LFS) patients. (PMID:25683625)
• MIR605 polymorphisms are associated with the risk of head and neck squamous cell carcinoma. (PMID:27515039)
• Low miR605 expression is associated with melanoma. (PMID:28656250)
• EN2 is negatively regulated by miR-605, and down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer (PCa) cells by up-regulating EN2, which leads to PCa development and progression (PMID:28943214)
• Circular RNA circ-VANGL1 is a competing endogenous RNA which contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway. (PMID:30146736)
• the findings of this meta-analysis did not support an association between miR-605 rs2043556 polymorphism and cancer susceptibility. (PMID:30514199)
• Current meta-analysis indicate that the miR-605 rs2043556 may decrease susceptibility in Asian populations, especially allelic-G may be a protective factor for cancer in carriers [Meta-analysis]. (PMID:30549993)
• this study highlights the important roles of BLACAT1/miR-605-3p/VASP axis in glioma progression. (PMID:31093978)
• miR-605-5p promotes invasion and proliferation by targeting TNFAIP3 in non-small-cell lung cancer. (PMID:31452243)
• Significant Association of miR-605 rs2043556 with Susceptibility to Breast Cancer. (PMID:31556863)
• microRNA-605 rs2043556 polymorphisms affect clopidogrel therapy through modulation of CYP2B6 and P2RY12 in acute coronary syndrome patients. (PMID:31766967)
• MIR605 rs2043556 is associated with the occurrence of multiple primary tumors in TP53 p.(Arg337His) mutation carriers. (PMID:31778928)
• SNHG16/miR-605-3p/TRAF6/NF-kappaB feedback loop regulates hepatocellular carcinoma metastasis. (PMID:32436333)
• CircDDX17 acts as a competing endogenous RNA for miR-605 in breast cancer progression. (PMID:32633371)
• Hsa-miR-605 regulates the proinflammatory chemokine CXCL5 in complex regional pain syndrome. (PMID:34062414)
• Long Noncoding RNA LINC01703 Exacerbates the Malignant Properties of Non-Small Cell Lung Cancer by Upregulating MACC1 in a MicroRNA-605-3p-Mediated Manner. (PMID:34493358)
• MicroRNA-605-3p Inhibited the Growth and Chemoresistance of Osteosarcoma Cells via Negatively Modulating RAF1. (PMID:39076089)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.