MIR606

Summary

MIR606 (microRNA 606, HGNC:32862) is a microRNA gene on chromosome 10q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693191 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32862
Approved symbol	MIR606
Name	microRNA 606
Location	10q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-606
Ensembl gene	ENSG00000207583
Ensembl biotype	miRNA
Entrez	693191
RNAcentral	URS000075AF3B — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384851

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384851 — 1 exons

Exon	Start	End
ENSE00001499858	75552458	75552553

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 92.66.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	92.66	gold quality
kidney	UBERON:0002113	87.64	gold quality
myometrium	UBERON:0001296	85.84	gold quality
liver	UBERON:0002107	85.37	gold quality
adrenal tissue	UBERON:0018303	84.20	gold quality
stomach	UBERON:0000945	80.01	gold quality
blood	UBERON:0000178	79.56	gold quality
endometrium	UBERON:0001295	79.01	gold quality
monocyte	CL:0000576	77.34	gold quality
fundus of stomach	UBERON:0001160	77.10	gold quality
heart	UBERON:0000948	74.40	gold quality
calcaneal tendon	UBERON:0003701	74.40	gold quality
adrenal gland	UBERON:0002369	74.13	gold quality
bone marrow	UBERON:0002371	73.30	gold quality
intestine	UBERON:0000160	72.44	gold quality
body of stomach	UBERON:0001161	72.10	gold quality
gastrocnemius	UBERON:0001388	71.99	gold quality
transverse colon	UBERON:0001157	71.64	gold quality
right lobe of thyroid gland	UBERON:0001119	70.49	gold quality
multicellular organism	UBERON:0000468	69.82	gold quality
amygdala	UBERON:0001876	69.60	gold quality
right atrium auricular region	UBERON:0006631	69.39	gold quality
heart left ventricle	UBERON:0002084	69.18	gold quality
tibial artery	UBERON:0007610	68.76	gold quality
colon	UBERON:0001155	68.58	gold quality
lung	UBERON:0002048	68.55	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.30	gold quality
left adrenal gland	UBERON:0001234	68.07	gold quality
right adrenal gland	UBERON:0001233	68.04	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MicroRNA-606 inhibits the growth and metastasis of triple-negative breast cancer by targeting Stanniocalcin 1. (PMID:37975233)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.