MIR6068

Summary

MIR6068 (microRNA 6068, HGNC:50261) is a microRNA gene on chromosome 1p31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464823 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50261
Approved symbol	MIR6068
Name	microRNA 6068
Location	1p31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6068
Ensembl gene	ENSG00000275836
Ensembl biotype	miRNA
Entrez	102464823
RNAcentral	URS000075CF78 — ncRNA, 60 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000615405

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000615405 — 1 exons

Exon	Start	End
ENSE00003735612	63326925	63326984

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 73.01.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	73.01	gold quality
monocyte	CL:0000576	72.73	gold quality
prostate gland	UBERON:0002367	72.38	gold quality
stomach	UBERON:0000945	71.03	gold quality
skin of abdomen	UBERON:0001416	70.79	gold quality
zone of skin	UBERON:0000014	70.52	gold quality
ascending aorta	UBERON:0001496	70.25	gold quality
heart left ventricle	UBERON:0002084	69.65	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.97	gold quality
skin of leg	UBERON:0001511	68.55	gold quality
amygdala	UBERON:0001876	67.44	gold quality
omental fat pad	UBERON:0010414	67.06	gold quality
transverse colon	UBERON:0001157	66.52	gold quality
colon	UBERON:0001155	66.36	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.27	gold quality
vagina	UBERON:0000996	66.15	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.78	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.74	gold quality
body of stomach	UBERON:0001161	65.53	gold quality
left ovary	UBERON:0002119	65.53	gold quality
right frontal lobe	UBERON:0002810	64.98	gold quality
tibial nerve	UBERON:0001323	64.41	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.39	gold quality
myometrium	UBERON:0001296	63.80	gold quality
thoracic mammary gland	UBERON:0005200	63.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.37	gold quality
hypothalamus	UBERON:0001898	62.90	gold quality
cerebellar hemisphere	UBERON:0002245	62.36	gold quality
caudate nucleus	UBERON:0001873	61.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.