MIR607

Summary

MIR607 (microRNA 607, HGNC:32863) is a microRNA gene on chromosome 10q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693192 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32863
Approved symbol	MIR607
Name	microRNA 607
Location	10q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-607
Ensembl gene	ENSG00000207976
Ensembl biotype	miRNA
Entrez	693192
RNAcentral	URS0000722917 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385241

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385241 — 1 exons

Exon	Start	End
ENSE00001500247	96828669	96828764

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 82.23.

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	82.23	gold quality
monocyte	CL:0000576	79.48	gold quality
skin of abdomen	UBERON:0001416	77.45	gold quality
left adrenal gland cortex	UBERON:0035825	71.69	gold quality
body of stomach	UBERON:0001161	71.23	gold quality
substantia nigra	UBERON:0002038	70.59	gold quality
tibial artery	UBERON:0007610	70.40	gold quality
liver	UBERON:0002107	69.53	gold quality
left adrenal gland	UBERON:0001234	69.26	gold quality
myometrium	UBERON:0001296	69.05	gold quality
amygdala	UBERON:0001876	66.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.43	gold quality
transverse colon	UBERON:0001157	65.95	gold quality
cerebellar hemisphere	UBERON:0002245	64.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.80	gold quality
nucleus accumbens	UBERON:0001882	64.74	gold quality
thoracic mammary gland	UBERON:0005200	64.42	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.34	gold quality
caudate nucleus	UBERON:0001873	64.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.01	gold quality
right frontal lobe	UBERON:0002810	63.90	gold quality
anterior cingulate cortex	UBERON:0009835	63.84	gold quality
putamen	UBERON:0001874	63.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.45	gold quality
Ammon’s horn	UBERON:0001954	63.17	gold quality
hypothalamus	UBERON:0001898	63.11	gold quality
thyroid gland	UBERON:0002046	63.01	gold quality
tibial nerve	UBERON:0001323	62.61	gold quality
left uterine tube	UBERON:0001303	62.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• This study identified Circular RNA circ-CBFB as a sponge of miR-607, which targeted FZD3. (PMID:29902450)
• the findings suggested that upregulation of TP73AS1 promoted cervical cancer progression by promoting CCND2 via the suppression of miR607 expression. (PMID:31432138)
• LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway. (PMID:31608998)
• Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma. (PMID:33879631)
• Low Serum miR-607 Level as a Potential Diagnostic and Prognostic Biomarker in Patients of Pancreatic Ductal Adenocarcinoma: A Preliminary Study. (PMID:34222137)
• [Overexpression of miR-607 inhibits hepatocellular carcinoma cell growth and metastasis by down-regulating TRPC5]. (PMID:36504050)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.