MIR6070

Summary

MIR6070 (microRNA 6070, HGNC:49950) is a microRNA gene on chromosome 21q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464825 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49950
Approved symbol	MIR6070
Name	microRNA 6070
Location	21q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6070
Ensembl gene	ENSG00000278433
Ensembl biotype	miRNA
Entrez	102464825
RNAcentral	URS000075A145 — ncRNA, 103 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613967

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613967 — 1 exons

Exon	Start	End
ENSE00003743001	43609887	43609989

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 84.57.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	84.57	gold quality
small intestine	UBERON:0002108	75.22	gold quality
stomach	UBERON:0000945	71.91	gold quality
body of pancreas	UBERON:0001150	71.90	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.01	gold quality
kidney	UBERON:0002113	70.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.20	gold quality
left uterine tube	UBERON:0001303	69.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.78	gold quality
nucleus accumbens	UBERON:0001882	68.95	gold quality
intestine	UBERON:0000160	68.48	gold quality
tibial artery	UBERON:0007610	68.04	gold quality
left ovary	UBERON:0002119	67.13	gold quality
cerebellar hemisphere	UBERON:0002245	66.22	gold quality
putamen	UBERON:0001874	66.20	gold quality
lung	UBERON:0002048	66.06	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.99	gold quality
thoracic mammary gland	UBERON:0005200	65.85	gold quality
left adrenal gland cortex	UBERON:0035825	65.68	gold quality
minor salivary gland	UBERON:0001830	65.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.28	gold quality
skin of leg	UBERON:0001511	64.87	gold quality
tibial nerve	UBERON:0001323	64.69	gold quality
skin of abdomen	UBERON:0001416	64.58	gold quality
myometrium	UBERON:0001296	63.29	gold quality
colon	UBERON:0001155	62.79	gold quality
body of uterus	UBERON:0009853	61.12	gold quality
amygdala	UBERON:0001876	60.51	gold quality
liver	UBERON:0002107	59.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.