MIR6071

Summary

MIR6071 (microRNA 6071, HGNC:50229) is a microRNA gene on chromosome 2p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466516 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50229
Approved symbol	MIR6071
Name	microRNA 6071
Location	2p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6071
Ensembl gene	ENSG00000278783
Ensembl biotype	miRNA
Entrez	102466516
RNAcentral	URS000075DA53 — ncRNA, 78 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616741

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616741 — 1 exons

Exon	Start	End
ENSE00003742014	85783600	85783677

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 86.96.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	86.96	gold quality
placenta	UBERON:0001987	78.44	gold quality
endometrium	UBERON:0001295	76.93	gold quality
muscle of leg	UBERON:0001383	75.87	gold quality
left lobe of thyroid gland	UBERON:0001120	75.75	gold quality
calcaneal tendon	UBERON:0003701	74.94	gold quality
right coronary artery	UBERON:0001625	74.89	gold quality
thyroid gland	UBERON:0002046	74.77	gold quality
gastrocnemius	UBERON:0001388	74.72	gold quality
lymph node	UBERON:0000029	74.32	gold quality
adenohypophysis	UBERON:0002196	74.17	gold quality
monocyte	CL:0000576	73.32	gold quality
right lobe of thyroid gland	UBERON:0001119	73.32	gold quality
heart left ventricle	UBERON:0002084	73.25	gold quality
gall bladder	UBERON:0002110	72.99	gold quality
heart	UBERON:0000948	72.75	gold quality
sural nerve	UBERON:0015488	72.64	gold quality
right atrium auricular region	UBERON:0006631	72.19	gold quality
prefrontal cortex	UBERON:0000451	71.61	gold quality
blood	UBERON:0000178	71.48	gold quality
right lung	UBERON:0002167	71.17	gold quality
liver	UBERON:0002107	71.07	gold quality
tibial artery	UBERON:0007610	70.93	gold quality
popliteal artery	UBERON:0002250	70.90	gold quality
tibial nerve	UBERON:0001323	70.55	gold quality
ascending aorta	UBERON:0001496	70.53	gold quality
thoracic aorta	UBERON:0001515	70.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.36	gold quality
right lobe of liver	UBERON:0001114	70.34	gold quality
left coronary artery	UBERON:0001626	70.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-6071 inhibits hepatocellular carcinoma progression via targeting PTPN11. (PMID:35792156)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.