MIR6072

Summary

MIR6072 (microRNA 6072, HGNC:50144) is a microRNA gene on chromosome 10p15.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465944 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50144
Approved symbol	MIR6072
Name	microRNA 6072
Location	10p15.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6072
Ensembl gene	ENSG00000278069
Ensembl biotype	miRNA
Entrez	102465944
RNAcentral	URS000075CD7F — ncRNA, 71 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622225

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622225 — 1 exons

Exon	Start	End
ENSE00003719710	2076019	2076089

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 64.06.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of abdomen	UBERON:0001416	64.06	gold quality
corpus callosum	UBERON:0002336	46.73	silver quality
left testis	UBERON:0004533	44.70	gold quality
right testis	UBERON:0004534	42.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.