MIR6073

Summary

MIR6073 (microRNA 6073, HGNC:50128) is a microRNA gene on chromosome 11p15.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464826 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50128
Approved symbol	MIR6073
Name	microRNA 6073
Location	11p15.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6073
Ensembl gene	ENSG00000284094
Ensembl biotype	miRNA
Entrez	102464826
RNAcentral	URS000075BE97 — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000352083

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000352083 — 1 exons

Exon	Start	End
ENSE00003727459	15969533	15969621

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 79.01.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	79.01	gold quality
skeletal muscle tissue	UBERON:0001134	78.60	gold quality
vermiform appendix	UBERON:0001154	77.36	gold quality
blood	UBERON:0000178	75.20	gold quality
caudate nucleus	UBERON:0001873	73.73	gold quality
muscle of leg	UBERON:0001383	73.06	gold quality
prefrontal cortex	UBERON:0000451	69.66	gold quality
left adrenal gland	UBERON:0001234	69.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.94	gold quality
liver	UBERON:0002107	67.60	silver quality
heart left ventricle	UBERON:0002084	67.26	gold quality
body of uterus	UBERON:0009853	66.14	gold quality
heart	UBERON:0000948	64.93	gold quality
right atrium auricular region	UBERON:0006631	64.04	gold quality
gastrocnemius	UBERON:0001388	63.83	gold quality
body of stomach	UBERON:0001161	63.45	gold quality
vagina	UBERON:0000996	63.11	gold quality
fundus of stomach	UBERON:0001160	62.52	gold quality
endometrium	UBERON:0001295	62.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.76	gold quality
gall bladder	UBERON:0002110	61.38	gold quality
multicellular organism	UBERON:0000468	60.85	gold quality
adrenal tissue	UBERON:0018303	59.98	gold quality
ascending aorta	UBERON:0001496	58.02	gold quality
tibial artery	UBERON:0007610	57.43	gold quality
left ovary	UBERON:0002119	57.22	gold quality
esophagus mucosa	UBERON:0002469	56.33	gold quality
myometrium	UBERON:0001296	55.80	gold quality
subcutaneous adipose tissue	UBERON:0002190	54.95	gold quality
tibial nerve	UBERON:0001323	54.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.