MIR6074

Summary

MIR6074 (microRNA 6074, HGNC:50060) is a microRNA gene on chromosome 12q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464827 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50060
Approved symbol	MIR6074
Name	microRNA 6074
Location	12q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6074
Ensembl gene	ENSG00000276878
Ensembl biotype	miRNA
Entrez	102464827
RNAcentral	URS000075D73C — miRNA, 107 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612054

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612054 — 1 exons

Exon	Start	End
ENSE00003736016	66023620	66023726

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 76.87.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	76.87	gold quality
body of stomach	UBERON:0001161	74.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.27	gold quality
skin of abdomen	UBERON:0001416	65.14	gold quality
right testis	UBERON:0004534	57.14	gold quality
left testis	UBERON:0004533	47.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.