MIR6075

Summary

MIR6075 (microRNA 6075, HGNC:50198) is a microRNA gene on chromosome 5p15.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466103 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50198
Approved symbol	MIR6075
Name	microRNA 6075
Location	5p15.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6075
Ensembl gene	ENSG00000273742
Ensembl biotype	miRNA
Entrez	102466103
RNAcentral	URS000075A781 — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000620782

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620782 — 1 exons

Exon	Start	End
ENSE00003737624	1510762	1510856

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 83.28.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.28	gold quality
bone marrow	UBERON:0002371	82.41	gold quality
blood	UBERON:0000178	81.29	gold quality
lymph node	UBERON:0000029	76.39	gold quality
gastrocnemius	UBERON:0001388	75.08	gold quality
body of pancreas	UBERON:0001150	74.81	gold quality
placenta	UBERON:0001987	74.48	gold quality
monocyte	CL:0000576	74.39	gold quality
lung	UBERON:0002048	72.39	gold quality
upper lobe of left lung	UBERON:0008952	71.63	gold quality
adrenal tissue	UBERON:0018303	71.58	gold quality
liver	UBERON:0002107	70.93	gold quality
right lung	UBERON:0002167	70.78	gold quality
metanephros cortex	UBERON:0010533	70.12	gold quality
endometrium	UBERON:0001295	69.99	gold quality
left adrenal gland cortex	UBERON:0035825	69.73	gold quality
right atrium auricular region	UBERON:0006631	69.72	gold quality
multicellular organism	UBERON:0000468	69.49	gold quality
left coronary artery	UBERON:0001626	69.46	gold quality
heart	UBERON:0000948	69.07	gold quality
ascending aorta	UBERON:0001496	68.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.78	gold quality
granulocyte	CL:0000094	68.73	gold quality
thoracic aorta	UBERON:0001515	68.60	gold quality
tibial artery	UBERON:0007610	68.46	gold quality
substantia nigra	UBERON:0002038	68.42	gold quality
popliteal artery	UBERON:0002250	68.35	gold quality
lower esophagus mucosa	UBERON:0035834	68.03	gold quality
body of stomach	UBERON:0001161	67.96	gold quality
right frontal lobe	UBERON:0002810	67.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.