MIR6076

Summary

MIR6076 (microRNA 6076, HGNC:50232) is a microRNA gene on chromosome 14q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464828 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50232
Approved symbol	MIR6076
Name	microRNA 6076
Location	14q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6076
Ensembl gene	ENSG00000278038
Ensembl biotype	miRNA
Entrez	102464828
RNAcentral	URS000075BE6D — ncRNA, 113 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617521

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617521 — 1 exons

Exon	Start	End
ENSE00003737266	49966399	49966511

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 83.63.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	83.63	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.94	gold quality
monocyte	CL:0000576	79.56	gold quality
saliva-secreting gland	UBERON:0001044	79.54	gold quality
blood	UBERON:0000178	77.13	gold quality
gastrocnemius	UBERON:0001388	75.49	gold quality
tibial artery	UBERON:0007610	73.71	gold quality
body of pancreas	UBERON:0001150	73.53	gold quality
lymph node	UBERON:0000029	72.40	gold quality
bone marrow	UBERON:0002371	71.56	gold quality
ascending aorta	UBERON:0001496	69.46	gold quality
body of stomach	UBERON:0001161	68.89	gold quality
urinary bladder	UBERON:0001255	68.69	gold quality
tibial nerve	UBERON:0001323	68.42	gold quality
thoracic aorta	UBERON:0001515	68.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.30	gold quality
vagina	UBERON:0000996	67.93	gold quality
right atrium auricular region	UBERON:0006631	67.92	gold quality
heart left ventricle	UBERON:0002084	67.74	gold quality
esophagus mucosa	UBERON:0002469	67.27	gold quality
hypothalamus	UBERON:0001898	67.03	gold quality
skin of abdomen	UBERON:0001416	66.82	gold quality
transverse colon	UBERON:0001157	66.80	gold quality
liver	UBERON:0002107	66.60	gold quality
stomach	UBERON:0000945	66.38	gold quality
colon	UBERON:0001155	66.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.21	gold quality
intestine	UBERON:0000160	66.17	gold quality
ectocervix	UBERON:0012249	65.90	gold quality
skin of leg	UBERON:0001511	65.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.