MIR6077

Summary

MIR6077 (microRNA 6077, HGNC:50025) is a microRNA gene on chromosome 1q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466225 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50025
Approved symbol	MIR6077
Name	microRNA 6077
Location	1q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6077-1, hsa-mir-6077-2
Ensembl gene	ENSG00000278596
Ensembl biotype	miRNA
Entrez	102466225
RNAcentral	URS000075AB26 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619691

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619691 — 1 exons

Exon	Start	End
ENSE00003728199	148388282	148388363

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 90.26.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	90.26	gold quality
bone marrow	UBERON:0002371	79.66	gold quality
blood	UBERON:0000178	77.28	gold quality
placenta	UBERON:0001987	77.01	gold quality
monocyte	CL:0000576	76.41	gold quality
gastrocnemius	UBERON:0001388	74.64	gold quality
adrenal tissue	UBERON:0018303	74.51	gold quality
ectocervix	UBERON:0012249	73.26	gold quality
heart	UBERON:0000948	72.06	gold quality
right coronary artery	UBERON:0001625	71.76	gold quality
liver	UBERON:0002107	71.60	gold quality
left uterine tube	UBERON:0001303	71.28	gold quality
adult mammalian kidney	UBERON:0000082	71.15	gold quality
lung	UBERON:0002048	71.06	gold quality
stomach	UBERON:0000945	70.63	gold quality
right atrium auricular region	UBERON:0006631	70.42	gold quality
right adrenal gland cortex	UBERON:0035827	70.22	gold quality
prefrontal cortex	UBERON:0000451	70.05	gold quality
heart left ventricle	UBERON:0002084	69.59	gold quality
islet of Langerhans	UBERON:0000006	69.13	gold quality
body of stomach	UBERON:0001161	68.94	gold quality
endometrium	UBERON:0001295	68.65	gold quality
fundus of stomach	UBERON:0001160	68.61	gold quality
ascending aorta	UBERON:0001496	68.48	gold quality
granulocyte	CL:0000094	68.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.84	gold quality
amygdala	UBERON:0001876	67.33	gold quality
frontal cortex	UBERON:0001870	67.17	gold quality
right lobe of liver	UBERON:0001114	66.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MicroRNA-6077 enhances the sensitivity of patients-derived lung adenocarcinoma cells to anlotinib by repressing the activation of glucose transporter 1 pathway. (PMID:31421224)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.