MIR6078

Summary

MIR6078 (microRNA 6078, HGNC:50136) is a microRNA gene on chromosome 10p15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464829 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50136
Approved symbol	MIR6078
Name	microRNA 6078
Location	10p15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6078
Ensembl gene	ENSG00000274809
Ensembl biotype	miRNA
Entrez	102464829
RNAcentral	URS000075E292 — miRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611069

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611069 — 1 exons

Exon	Start	End
ENSE00003736037	3991160	3991259

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 77.28.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial artery	UBERON:0007610	77.28	gold quality
endometrium	UBERON:0001295	76.70	gold quality
body of uterus	UBERON:0009853	74.97	gold quality
lung	UBERON:0002048	72.26	gold quality
adrenal tissue	UBERON:0018303	71.21	gold quality
omental fat pad	UBERON:0010414	70.33	gold quality
colon	UBERON:0001155	69.68	gold quality
pituitary gland	UBERON:0000007	68.48	gold quality
left ovary	UBERON:0002119	68.46	gold quality
ovary	UBERON:0000992	68.13	gold quality
right ovary	UBERON:0002118	67.50	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.13	gold quality
Ammon’s horn	UBERON:0001954	66.92	gold quality
fallopian tube	UBERON:0003889	64.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.35	gold quality
minor salivary gland	UBERON:0001830	64.26	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.22	gold quality
vagina	UBERON:0000996	63.93	gold quality
cerebral cortex	UBERON:0000956	63.82	gold quality
tibial nerve	UBERON:0001323	63.43	gold quality
anterior cingulate cortex	UBERON:0009835	62.86	gold quality
myometrium	UBERON:0001296	59.84	gold quality
right frontal lobe	UBERON:0002810	56.60	gold quality
left testis	UBERON:0004533	51.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.