MIR6081

Summary

MIR6081 (microRNA 6081, HGNC:50151) is a microRNA gene on chromosome 9q22.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466518 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50151
Approved symbol	MIR6081
Name	microRNA 6081
Location	9q22.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6081
Ensembl gene	ENSG00000274115
Ensembl biotype	miRNA
Entrez	102466518
RNAcentral	URS000075E2FC — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000613785

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000613785 — 1 exons

Exon	Start	End
ENSE00003730575	95065350	95065446

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 91.93.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	91.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.04	gold quality
adrenal tissue	UBERON:0018303	88.11	gold quality
adult mammalian kidney	UBERON:0000082	86.38	gold quality
calcaneal tendon	UBERON:0003701	81.02	gold quality
liver	UBERON:0002107	80.65	gold quality
stomach	UBERON:0000945	77.70	gold quality
blood	UBERON:0000178	77.26	gold quality
muscle of leg	UBERON:0001383	76.44	gold quality
ectocervix	UBERON:0012249	74.57	gold quality
gastrocnemius	UBERON:0001388	74.51	gold quality
placenta	UBERON:0001987	73.52	gold quality
lung	UBERON:0002048	73.26	gold quality
body of pancreas	UBERON:0001150	72.53	gold quality
ascending aorta	UBERON:0001496	72.40	gold quality
thoracic aorta	UBERON:0001515	72.25	gold quality
tibial artery	UBERON:0007610	72.08	gold quality
heart	UBERON:0000948	72.06	gold quality
popliteal artery	UBERON:0002250	72.03	gold quality
body of uterus	UBERON:0009853	71.72	gold quality
substantia nigra	UBERON:0002038	71.52	gold quality
right atrium auricular region	UBERON:0006631	71.22	gold quality
body of stomach	UBERON:0001161	71.15	gold quality
myometrium	UBERON:0001296	70.84	gold quality
heart left ventricle	UBERON:0002084	70.80	gold quality
colon	UBERON:0001155	70.44	gold quality
skin of abdomen	UBERON:0001416	70.23	gold quality
descending thoracic aorta	UBERON:0002345	70.14	gold quality
islet of Langerhans	UBERON:0000006	70.02	gold quality
right adrenal gland	UBERON:0001233	69.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.