MIR6083

Summary

MIR6083 (microRNA 6083, HGNC:50076) is a microRNA gene on chromosome 3q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464832 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50076
Approved symbol	MIR6083
Name	microRNA 6083
Location	3q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6083
Ensembl gene	ENSG00000276656
Ensembl biotype	miRNA
Entrez	102464832
RNAcentral	URS000075EBE3 — miRNA, 106 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612737

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612737 — 1 exons

Exon	Start	End
ENSE00003720271	124374332	124374437

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 91.39.

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.39	gold quality
lung	UBERON:0002048	85.99	gold quality
kidney	UBERON:0002113	85.32	gold quality
body of pancreas	UBERON:0001150	82.20	gold quality
blood	UBERON:0000178	81.15	gold quality
calcaneal tendon	UBERON:0003701	77.08	gold quality
intestine	UBERON:0000160	76.05	gold quality
stomach	UBERON:0000945	75.95	gold quality
tibial nerve	UBERON:0001323	74.81	gold quality
colon	UBERON:0001155	74.06	gold quality
gastrocnemius	UBERON:0001388	73.08	gold quality
body of uterus	UBERON:0009853	73.06	gold quality
heart	UBERON:0000948	72.99	gold quality
ascending aorta	UBERON:0001496	72.18	gold quality
heart left ventricle	UBERON:0002084	72.10	gold quality
left adrenal gland cortex	UBERON:0035825	71.75	gold quality
thoracic aorta	UBERON:0001515	71.73	gold quality
left coronary artery	UBERON:0001626	71.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.38	gold quality
left adrenal gland	UBERON:0001234	71.18	gold quality
hypothalamus	UBERON:0001898	71.16	gold quality
corpus callosum	UBERON:0002336	70.68	gold quality
tibial artery	UBERON:0007610	69.64	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.63	gold quality
right atrium auricular region	UBERON:0006631	69.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.40	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.23	gold quality
transverse colon	UBERON:0001157	68.55	gold quality
adrenal tissue	UBERON:0018303	68.13	gold quality
descending thoracic aorta	UBERON:0002345	67.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.