MIR6085

Summary

MIR6085 (microRNA 6085, HGNC:50002) is a microRNA gene on chromosome 15q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464834 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50002
Approved symbol	MIR6085
Name	microRNA 6085
Location	15q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6085
Ensembl gene	ENSG00000275451
Ensembl biotype	miRNA
Entrez	102464834
RNAcentral	URS000075E9E9 — miRNA, 110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618314

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618314 — 1 exons

Exon	Start	End
ENSE00003754565	62343029	62343138

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 78.72.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.72	gold quality
islet of Langerhans	UBERON:0000006	74.37	gold quality
body of pancreas	UBERON:0001150	69.24	gold quality
anterior cingulate cortex	UBERON:0009835	67.79	gold quality
blood	UBERON:0000178	67.75	gold quality
esophagus mucosa	UBERON:0002469	67.63	gold quality
putamen	UBERON:0001874	66.36	gold quality
nucleus accumbens	UBERON:0001882	65.74	gold quality
right lobe of thyroid gland	UBERON:0001119	65.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.24	gold quality
transverse colon	UBERON:0001157	65.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.84	gold quality
colon	UBERON:0001155	63.52	gold quality
adenohypophysis	UBERON:0002196	62.09	gold quality
thyroid gland	UBERON:0002046	62.07	gold quality
lung	UBERON:0002048	62.07	gold quality
left lobe of thyroid gland	UBERON:0001120	61.97	gold quality
pituitary gland	UBERON:0000007	61.38	gold quality
thoracic mammary gland	UBERON:0005200	60.04	gold quality
frontal cortex	UBERON:0001870	59.17	gold quality
caudate nucleus	UBERON:0001873	59.03	gold quality
upper lobe of left lung	UBERON:0008952	58.86	gold quality
right testis	UBERON:0004534	54.58	gold quality
right frontal lobe	UBERON:0002810	51.27	gold quality
left testis	UBERON:0004533	49.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.