MIR6086

Summary

MIR6086 (microRNA 6086, HGNC:49986) is a microRNA gene on chromosome Xp22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466519 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49986
Approved symbol	MIR6086
Name	microRNA 6086
Location	Xp22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6086
Ensembl gene	ENSG00000283493
Ensembl biotype	miRNA
Entrez	102466519
RNAcentral	URS000075EA84 — miRNA, 55 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000638065

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638065 — 1 exons

Exon	Start	End
ENSE00003794873	13590292	13590346

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 74.35.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	74.35	gold quality
monocyte	CL:0000576	72.59	gold quality
lung	UBERON:0002048	72.24	gold quality
spleen	UBERON:0002106	71.78	gold quality
skin of leg	UBERON:0001511	69.38	gold quality
endometrium	UBERON:0001295	69.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.41	gold quality
stomach	UBERON:0000945	66.55	gold quality
esophagus mucosa	UBERON:0002469	66.37	gold quality
omental fat pad	UBERON:0010414	66.22	gold quality
tibial nerve	UBERON:0001323	65.95	gold quality
skin of abdomen	UBERON:0001416	65.95	gold quality
pituitary gland	UBERON:0000007	63.83	gold quality
upper lobe of left lung	UBERON:0008952	63.45	gold quality
left testis	UBERON:0004533	47.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• hsa-miR-6086 is induced by TNFalpha and mediates TNFalpha-induced HUVEC growth inhibition through downregulating CDH5 expression. Hence, hsa-miR-6086 might be a new target for treating TNFalpha-induced endothelial dysfunction. (PMID:29605606)
• miR-6086 inhibits ovarian cancer angiogenesis by downregulating the OC2/VEGFA/EGFL6 axis. (PMID:32393810)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.