MIR6088

Summary

MIR6088 (microRNA 6088, HGNC:50164) is a microRNA gene on chromosome 19q13.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464836 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50164
Approved symbol	MIR6088
Name	microRNA 6088
Location	19q13.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6088
Ensembl gene	ENSG00000275726
Ensembl biotype	miRNA
Entrez	102464836
RNAcentral	URS000075C97D — miRNA, 51 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611232

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611232 — 1 exons

Exon	Start	End
ENSE00003724795	45436654	45436704

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 88.10.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	88.10	gold quality
blood	UBERON:0000178	77.40	gold quality
calcaneal tendon	UBERON:0003701	76.96	gold quality
stomach	UBERON:0000945	73.41	gold quality
urinary bladder	UBERON:0001255	71.91	gold quality
heart left ventricle	UBERON:0002084	71.61	gold quality
body of stomach	UBERON:0001161	71.23	gold quality
left adrenal gland	UBERON:0001234	71.10	gold quality
right atrium auricular region	UBERON:0006631	71.04	gold quality
tibial artery	UBERON:0007610	70.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.55	gold quality
skin of abdomen	UBERON:0001416	69.43	gold quality
endometrium	UBERON:0001295	69.38	gold quality
body of uterus	UBERON:0009853	69.36	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.19	gold quality
omental fat pad	UBERON:0010414	68.17	gold quality
ascending aorta	UBERON:0001496	68.14	gold quality
thoracic mammary gland	UBERON:0005200	68.01	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.77	gold quality
skin of leg	UBERON:0001511	67.65	gold quality
transverse colon	UBERON:0001157	67.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.48	gold quality
vagina	UBERON:0000996	67.44	gold quality
right adrenal gland cortex	UBERON:0035827	67.39	gold quality
right frontal lobe	UBERON:0002810	67.13	gold quality
right lobe of thyroid gland	UBERON:0001119	66.76	gold quality
nucleus accumbens	UBERON:0001882	66.70	gold quality
putamen	UBERON:0001874	66.03	gold quality
spleen	UBERON:0002106	65.37	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Tumor-Suppressive Function of lncRNA-MEG3 in Glioma Cells by Regulating miR-6088/SMARCB1 Axis. (PMID:32420340)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.