MIR609

Summary

MIR609 (microRNA 609, HGNC:32865) is a microRNA gene on chromosome 10q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693194 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32865
Approved symbol	MIR609
Name	microRNA 609
Location	10q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-609
Ensembl gene	ENSG00000208033
Ensembl biotype	miRNA
Entrez	693194
RNAcentral	URS00006E8036 — miRNA, 95 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385298

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385298 — 1 exons

Exon	Start	End
ENSE00001500304	104218789	104218883

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 80.62.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	80.62	gold quality
transverse colon	UBERON:0001157	75.24	gold quality
monocyte	CL:0000576	74.98	gold quality
body of pancreas	UBERON:0001150	74.52	gold quality
blood	UBERON:0000178	73.01	gold quality
kidney	UBERON:0002113	72.93	gold quality
right adrenal gland	UBERON:0001233	72.61	gold quality
lung	UBERON:0002048	71.61	gold quality
body of stomach	UBERON:0001161	71.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.98	gold quality
endometrium	UBERON:0001295	70.77	gold quality
right uterine tube	UBERON:0001302	70.51	gold quality
right atrium auricular region	UBERON:0006631	70.43	gold quality
right lobe of liver	UBERON:0001114	69.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.31	gold quality
left uterine tube	UBERON:0001303	68.23	gold quality
omental fat pad	UBERON:0010414	67.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.78	gold quality
amygdala	UBERON:0001876	66.74	gold quality
skin of leg	UBERON:0001511	66.52	gold quality
Ammon’s horn	UBERON:0001954	66.48	gold quality
skin of abdomen	UBERON:0001416	65.95	gold quality
right frontal lobe	UBERON:0002810	65.37	gold quality
minor salivary gland	UBERON:0001830	65.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.76	gold quality
hypothalamus	UBERON:0001898	64.67	gold quality
caudate nucleus	UBERON:0001873	64.01	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.06	gold quality
left ovary	UBERON:0002119	62.97	gold quality
myometrium	UBERON:0001296	62.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• increased level of serum miR-609 in patients with thalassemia is a risk factor for poor prognosis and can be used as a reference index for evaluating the efficacy for patients (PMID:31839062)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.