MIR6090

Summary

MIR6090 (microRNA 6090, HGNC:50204) is a microRNA gene on chromosome 11q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466104 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50204
Approved symbol	MIR6090
Name	microRNA 6090
Location	11q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6090
Ensembl gene	ENSG00000276176
Ensembl biotype	miRNA
Entrez	102466104
RNAcentral	URS000075B8AB — ncRNA, 60 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622481

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622481 — 1 exons

Exon	Start	End
ENSE00003719457	128522390	128522449

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 75.38.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	75.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.30	gold quality
tibial artery	UBERON:0007610	74.98	gold quality
blood	UBERON:0000178	74.83	gold quality
liver	UBERON:0002107	73.37	gold quality
lung	UBERON:0002048	72.85	gold quality
leukocyte	CL:0000738	71.51	gold quality
right lobe of liver	UBERON:0001114	70.90	gold quality
heart left ventricle	UBERON:0002084	70.82	gold quality
amygdala	UBERON:0001876	70.56	gold quality
heart	UBERON:0000948	70.03	gold quality
transverse colon	UBERON:0001157	69.38	gold quality
thoracic mammary gland	UBERON:0005200	68.01	gold quality
body of stomach	UBERON:0001161	67.99	gold quality
ascending aorta	UBERON:0001496	67.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.60	gold quality
omental fat pad	UBERON:0010414	67.58	gold quality
skin of leg	UBERON:0001511	67.19	gold quality
upper lobe of left lung	UBERON:0008952	67.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.47	gold quality
left lobe of thyroid gland	UBERON:0001120	66.27	gold quality
endometrium	UBERON:0001295	65.71	gold quality
right ovary	UBERON:0002118	65.57	gold quality
anterior cingulate cortex	UBERON:0009835	65.37	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.04	gold quality
putamen	UBERON:0001874	64.61	gold quality
stomach	UBERON:0000945	64.24	gold quality
body of uterus	UBERON:0009853	64.03	gold quality
skin of abdomen	UBERON:0001416	63.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.79

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.