MIR610

Summary

MIR610 (microRNA 610, HGNC:32866) is a microRNA gene on chromosome 11p14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693195 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32866
Approved symbol	MIR610
Name	microRNA 610
Location	11p14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-610
Ensembl gene	ENSG00000207874
Ensembl biotype	miRNA
OMIM	612330
Entrez	693195
RNAcentral	URS000075D59C — miRNA, 96 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385139

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385139 — 1 exons

Exon	Start	End
ENSE00001500145	28056815	28056910

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 87.62.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	87.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.38	gold quality
heart	UBERON:0000948	81.94	gold quality
kidney	UBERON:0002113	76.94	gold quality
endometrium	UBERON:0001295	76.03	gold quality
right lobe of liver	UBERON:0001114	72.35	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.45	gold quality
skin of leg	UBERON:0001511	70.22	gold quality
body of stomach	UBERON:0001161	70.13	gold quality
lung	UBERON:0002048	69.63	gold quality
transverse colon	UBERON:0001157	68.79	gold quality
blood	UBERON:0000178	68.47	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.12	gold quality
ascending aorta	UBERON:0001496	65.78	gold quality
left lobe of thyroid gland	UBERON:0001120	64.54	gold quality
esophagus mucosa	UBERON:0002469	63.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.75	gold quality
left adrenal gland	UBERON:0001234	60.68	gold quality
right frontal lobe	UBERON:0002810	51.03	gold quality
left testis	UBERON:0004533	43.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• we demonstrated that miR610-mediated inhibition of VASP expression resulted in a significant reduction in the migration and invasion properties of gastric cancer cells. (PMID:22189055)
• Inhibition of miR-610 promoted, but overexpression of miR-610 reduced, HCC cell proliferation. (PMID:25491321)
• Bioinformatics analysis further revealed cyclin D2 (CCND2) and AKT3, putative tumor promoters, as potential targets of miR610. Data from reporter assays showed that miR610 directly binds to the 3’untranslated (PMID:26782072)
• the present study is the first to provide evidence suggesting that miR610 directly targets MDM2 proto-oncogene E3 ubiquitin protein ligase to function as a tumor suppressor in glioma. (PMID:27485527)
• FEZF1-AS1 promoted multiple myeloma cells proliferation through regulating miR-610/Akt3 axis. (PMID:29864963)
• miR-610 expression was significantly downregulated in both oral squamous cell carcinoma (OSCC) tissues and cell lines. Low miR-610 expression was associated with advanced T classification, TNM stage and poorer prognosis. Overexpression of miR-610 significantly suppressed OSCC cells proliferation, migration, invasion and EMT process. Mechanistically, AGK was confirmed to be the downstream target of miR-610 in OSCC cells. (PMID:30657560)
• Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610. (PMID:36243865)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.