MIR611

Summary

MIR611 (microRNA 611, HGNC:32867) is a microRNA gene on chromosome 11q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693196 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32867
Approved symbol	MIR611
Name	microRNA 611
Location	11q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-611
Ensembl gene	ENSG00000284108
Ensembl biotype	miRNA
Entrez	693196
RNAcentral	URS0000643E32 — miRNA, 67 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384869

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384869 — 1 exons

Exon	Start	End
ENSE00001499876	61792495	61792561

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 84.60.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	84.60	gold quality
heart left ventricle	UBERON:0002084	74.55	gold quality
body of stomach	UBERON:0001161	69.15	gold quality
body of pancreas	UBERON:0001150	68.68	gold quality
blood	UBERON:0000178	64.98	gold quality
gastrocnemius	UBERON:0001388	63.40	gold quality
vagina	UBERON:0000996	61.29	gold quality
left adrenal gland cortex	UBERON:0035825	61.24	gold quality
caudate nucleus	UBERON:0001873	58.59	gold quality
cerebellar hemisphere	UBERON:0002245	58.42	gold quality
prostate gland	UBERON:0002367	55.63	gold quality
skin of leg	UBERON:0001511	54.72	gold quality
anterior cingulate cortex	UBERON:0009835	52.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	48.63	gold quality
thyroid gland	UBERON:0002046	48.47	gold quality
right hemisphere of cerebellum	UBERON:0014890	48.19	silver quality
small intestine Peyer’s patch	UBERON:0003454	42.65	silver quality
tibial nerve	UBERON:0001323	41.82	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Overexpression of microRNA-611 inhibits TGF-beta-induced epithelial-mesenchymal transition and migration in lung cancer cells through MAPKAP1. (PMID:39173858)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.