MIR612

Summary

MIR612 (microRNA 612, HGNC:32868) is a microRNA gene on chromosome 11q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693197 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32868
Approved symbol	MIR612
Name	microRNA 612
Location	11q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-612
Ensembl gene	ENSG00000283791
Ensembl biotype	miRNA
Entrez	693197
RNAcentral	URS00006E8395 — miRNA, 100 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384994

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384994 — 1 exons

Exon	Start	End
ENSE00002688555	65444458	65444557

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 96.60.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.60	gold quality
muscle of leg	UBERON:0001383	75.72	gold quality
skin of leg	UBERON:0001511	74.31	gold quality
placenta	UBERON:0001987	74.04	gold quality
gastrocnemius	UBERON:0001388	73.60	gold quality
blood	UBERON:0000178	73.49	gold quality
omental fat pad	UBERON:0010414	70.56	gold quality
lymph node	UBERON:0000029	69.32	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.65	gold quality
caudate nucleus	UBERON:0001873	67.73	gold quality
heart left ventricle	UBERON:0002084	67.28	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.48	gold quality
Ammon’s horn	UBERON:0001954	64.11	gold quality
multicellular organism	UBERON:0000468	63.41	gold quality
amygdala	UBERON:0001876	62.99	gold quality
spleen	UBERON:0002106	62.72	gold quality
left ovary	UBERON:0002119	62.06	gold quality
body of uterus	UBERON:0009853	61.63	gold quality
tibial artery	UBERON:0007610	61.58	gold quality
anterior cingulate cortex	UBERON:0009835	60.96	gold quality
substantia nigra	UBERON:0002038	59.38	gold quality
vagina	UBERON:0000996	59.18	gold quality
colon	UBERON:0001155	59.06	gold quality
right frontal lobe	UBERON:0002810	57.98	gold quality
upper lobe of left lung	UBERON:0008952	56.86	gold quality
right lobe of liver	UBERON:0001114	56.79	gold quality
hypothalamus	UBERON:0001898	56.38	gold quality
cerebellar hemisphere	UBERON:0002245	55.39	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	55.31	gold quality
right hemisphere of cerebellum	UBERON:0014890	54.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 18)

• The two SNPs within miR-612 significantly affected expression of mature miR-612 in a cell-type specific manner; enhancement in prostate cancer cell lines, reduction in colon cancer cells, and no effect in breast cancer cell lines. (PMID:23077621)
• miR-612 is involved in both the initial and final steps of the metastatic cascade, by suppressing local invasion and distant colonization. (PMID:23478189)
• rs12803915 in mir-612 exhibited a significant association with pediatric acute lymphoblastic leukemia. (PMID:24618566)
• findings suggest that Wnt/beta-catenin signaling is required in the regulation of epithelial-mesenchymal transition -associated stem cell-like traits by miR-612. (PMID:24704424)
• These results were additionally validated in vivo by tumorigenesis and liver metastasis experiments. The results of this study suggested a critical role of miR-612 in the development of Colorectal cancer (PMID:26158514)
• miR-612 has a suppressive role on hepatocellular carcinoma cell stemness via Sp1/Nanog signaling pathway. (PMID:27685621)
• miR612 is identified as associated with esophageal squamous cell carcinoma development and metastasis, likely through the regulation of TP53 expression. (PMID:28656264)
• significant inverse correlation was observed between miR-612 and Espin protein expression in melanoma tissues. (PMID:29385671)
• Results provided evidence indicating that miR612 expression is downregulated in bladder cancer tissues and cell lines, and that decreased miR612 expression is associated with advanced bladder cancer TNM stages and distant metastasis. further suggested that miR612 expression was able to inhibit bladder cancer cell growth, colony formation, migration, invasion and EMT through directly targeting the expression of ME1. (PMID:29620192)
• The bioinformatic prediction revealed that TP53 was a putative target gene of miR-612 and CD40 of miR-1976. Moreover, TP53 was downregulated in the expression array when comparing HR vs LR expression levels adjusted by sex, diet, age and baseline weight, and CD40 showed a statistical trend. (PMID:30089130)
• LINC01061 sponges miR-612 to increase SEMA4D expression. (PMID:30967271)
• The current investigation uncovered the molecular mechanism underlying miR-612 in Neurofibromatosis type I, establishing miR-612 as a novel therapeutic target for the treatment of Neurofibromatosis type I patients. (PMID:31197610)
• Downregulated long noncoding RNA LUCAT1 inhibited proliferation and promoted apoptosis of cardiomyocyte via miR-612/HOXA13 pathway in chronic heart failure. (PMID:31957853)
• MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming. (PMID:32033570)
• LINC00460 Enhances Bladder Carcinoma Cell Proliferation and Migration by Modulating miR-612/FOXK1 Axis. (PMID:33027786)
• Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612. (PMID:34802444)
• LINC01061 triggers inflammation and inflammasome activation in autoimmune thyroiditis via microRNA-612/BRD4 axis. (PMID:35998503)
• Association of MIR3117 and MIR612 Genes Polymorphisms with Childhood Acute Lymphoblastic Leukemia in the Mexican Population. (PMID:36002354)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.