MIR6124

Summary

MIR6124 (microRNA 6124, HGNC:50200) is a microRNA gene on chromosome 11p15.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466906 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50200
Approved symbol	MIR6124
Name	microRNA 6124
Location	11p15.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6124
Ensembl gene	ENSG00000275373
Ensembl biotype	miRNA
Entrez	102466906
RNAcentral	URS000075BAD8 — ncRNA, 85 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617177

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617177 — 1 exons

Exon	Start	End
ENSE00003715949	12163683	12163767

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 82.09.

Top tissues by expression

84 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.09	gold quality
adrenal tissue	UBERON:0018303	80.83	gold quality
monocyte	CL:0000576	80.80	gold quality
calcaneal tendon	UBERON:0003701	79.12	gold quality
fundus of stomach	UBERON:0001160	75.73	gold quality
smooth muscle tissue	UBERON:0001135	73.88	gold quality
muscle of leg	UBERON:0001383	73.71	gold quality
left coronary artery	UBERON:0001626	73.12	gold quality
stomach	UBERON:0000945	73.00	gold quality
liver	UBERON:0002107	72.99	gold quality
gastrocnemius	UBERON:0001388	72.68	gold quality
heart	UBERON:0000948	72.43	gold quality
ascending aorta	UBERON:0001496	72.31	gold quality
mucosa of stomach	UBERON:0001199	72.21	gold quality
lymph node	UBERON:0000029	72.00	gold quality
thoracic aorta	UBERON:0001515	71.70	gold quality
left adrenal gland	UBERON:0001234	71.60	gold quality
left adrenal gland cortex	UBERON:0035825	71.19	gold quality
right adrenal gland cortex	UBERON:0035827	70.98	gold quality
heart left ventricle	UBERON:0002084	70.71	gold quality
right atrium auricular region	UBERON:0006631	70.51	gold quality
mucosa of transverse colon	UBERON:0004991	70.32	gold quality
body of uterus	UBERON:0009853	70.11	gold quality
cerebellar hemisphere	UBERON:0002245	69.85	gold quality
body of stomach	UBERON:0001161	69.36	gold quality
right lobe of liver	UBERON:0001114	69.30	gold quality
popliteal artery	UBERON:0002250	68.86	gold quality
tibial artery	UBERON:0007610	68.79	gold quality
adult mammalian kidney	UBERON:0000082	68.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-6124 consists of only purine bases. (PMID:29967426)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.