MIR6125

Summary

MIR6125 (microRNA 6125, HGNC:49931) is a microRNA gene on chromosome 12q14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465133 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49931
Approved symbol	MIR6125
Name	microRNA 6125
Location	12q14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6125
Ensembl gene	ENSG00000284360
Ensembl biotype	miRNA
Entrez	102465133
RNAcentral	URS000075E538 — ncRNA, 96 nt, 15 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000618986

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618986 — 1 exons

Exon	Start	End
ENSE00001358609	62260359	62260454

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 93.70.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2718 / max 33.9493, expressed in 721 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126381	1.2718	721

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.70	gold quality
fundus of stomach	UBERON:0001160	73.28	gold quality
blood	UBERON:0000178	69.58	gold quality
stomach	UBERON:0000945	67.88	gold quality
gastrocnemius	UBERON:0001388	67.57	gold quality
body of pancreas	UBERON:0001150	67.40	gold quality
right lung	UBERON:0002167	67.37	gold quality
body of stomach	UBERON:0001161	67.36	gold quality
amygdala	UBERON:0001876	65.93	gold quality
right ovary	UBERON:0002118	65.87	gold quality
anterior cingulate cortex	UBERON:0009835	65.06	gold quality
left ovary	UBERON:0002119	64.37	gold quality
left coronary artery	UBERON:0001626	64.16	gold quality
right frontal lobe	UBERON:0002810	63.94	gold quality
transverse colon	UBERON:0001157	63.72	gold quality
spleen	UBERON:0002106	63.36	gold quality
descending thoracic aorta	UBERON:0002345	63.30	gold quality
colon	UBERON:0001155	62.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.63	gold quality
Ammon’s horn	UBERON:0001954	62.59	gold quality
heart left ventricle	UBERON:0002084	62.54	gold quality
left adrenal gland	UBERON:0001234	62.50	gold quality
omental fat pad	UBERON:0010414	62.13	gold quality
esophagus mucosa	UBERON:0002469	61.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.33	gold quality
tibial artery	UBERON:0007610	61.31	gold quality
left adrenal gland cortex	UBERON:0035825	61.29	gold quality
tibial nerve	UBERON:0001323	61.05	gold quality
minor salivary gland	UBERON:0001830	60.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer. (PMID:34011306)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.