MIR6126

Summary

MIR6126 (microRNA 6126, HGNC:50099) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465134 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50099
Approved symbol	MIR6126
Name	microRNA 6126
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6126
Ensembl gene	ENSG00000273776
Ensembl biotype	miRNA
Entrez	102465134
RNAcentral	URS000075DE21 — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000622849

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622849 — 1 exons

Exon	Start	End
ENSE00003747468	3485381	3485469

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 87.58.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	87.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.96	gold quality
adrenal tissue	UBERON:0018303	71.09	gold quality
right lobe of thyroid gland	UBERON:0001119	69.40	gold quality
islet of Langerhans	UBERON:0000006	69.06	gold quality
omental fat pad	UBERON:0010414	68.52	gold quality
blood	UBERON:0000178	67.48	gold quality
liver	UBERON:0002107	66.67	gold quality
gastrocnemius	UBERON:0001388	65.75	gold quality
skin of leg	UBERON:0001511	62.00	gold quality
nucleus accumbens	UBERON:0001882	61.93	gold quality
heart left ventricle	UBERON:0002084	61.40	gold quality
esophagus mucosa	UBERON:0002469	61.20	gold quality
putamen	UBERON:0001874	56.41	gold quality
body of pancreas	UBERON:0001150	55.81	gold quality
vagina	UBERON:0000996	54.93	gold quality
amygdala	UBERON:0001876	54.61	gold quality
stomach	UBERON:0000945	53.33	gold quality
hypothalamus	UBERON:0001898	50.23	gold quality
right atrium auricular region	UBERON:0006631	48.07	gold quality
Ammon’s horn	UBERON:0001954	47.79	gold quality
right ovary	UBERON:0002118	46.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• we report that miR-6126 is ubiquitously released in high abundance from both chemosensitive and chemoresistant ovarian cancer cells via exosomes (PMID:27742688)
• high serum miR-6126 levels during Peg-IFN therapy predicted the HBsAg 1-log drop 48 weeks after the completion of therapy. In vitro assays revealed that miR-6126 was able to suppress HBsAg production and HBV replication. (PMID:30004437)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.