MIR6127

Summary

MIR6127 (microRNA 6127, HGNC:50163) is a microRNA gene on chromosome 1p36.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466615 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50163
Approved symbol	MIR6127
Name	microRNA 6127
Location	1p36.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-6127
Ensembl gene	ENSG00000276835
Ensembl biotype	miRNA
Entrez	102466615
RNAcentral	URS000075F071 — miRNA, 109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000614019

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000614019 — 1 exons

Exon	Start	End
ENSE00003723861	22633258	22633366

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 76.47.

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.47	gold quality
transverse colon	UBERON:0001157	74.01	gold quality
left ovary	UBERON:0002119	71.97	gold quality
tibial artery	UBERON:0007610	70.94	gold quality
gastrocnemius	UBERON:0001388	70.75	gold quality
ovary	UBERON:0000992	69.62	gold quality
myometrium	UBERON:0001296	69.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.17	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.04	gold quality
esophagus mucosa	UBERON:0002469	68.64	gold quality
left adrenal gland	UBERON:0001234	68.63	gold quality
anterior cingulate cortex	UBERON:0009835	68.52	gold quality
right lobe of liver	UBERON:0001114	68.36	gold quality
body of stomach	UBERON:0001161	67.40	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.09	gold quality
right adrenal gland	UBERON:0001233	66.92	gold quality
minor salivary gland	UBERON:0001830	66.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.63	gold quality
tibial nerve	UBERON:0001323	66.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.26	gold quality
ascending aorta	UBERON:0001496	66.18	gold quality
omental fat pad	UBERON:0010414	65.91	gold quality
left adrenal gland cortex	UBERON:0035825	65.46	gold quality
skin of leg	UBERON:0001511	64.45	gold quality
spleen	UBERON:0002106	63.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.47	gold quality
thyroid gland	UBERON:0002046	62.20	gold quality
pituitary gland	UBERON:0000007	60.30	gold quality
right testis	UBERON:0004534	47.87	gold quality
left testis	UBERON:0004533	46.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.